Glycinebetaine
Glycinebetaine Uses, Dosage, Side Effects, Food Interaction and all others data.
Glycinebetaine is a methyl group donor that functions in the normal metabolic cycle of methionine and reduces homocystinuria in patients with inborn errors of methionine metabolism. In the United States, betaine is distributed under the brand name Cystadane® by Rare Disease Therapeutics. Many reports have shown that betaine's therapeutic effectiveness is limited, and does not lower tHcy levels or prevent clinical symptoms [2].
| Trade Name | Glycinebetaine |
| Availability | Prescription only |
| Generic | Betaine |
| Betaine Other Names | 2-trimethylammonioacetate, Abromine, Acidol, Betaína anhidra, Betaine, Glycine betaine, Glycinebetaine, Glykokollbetain, N,N,N-Trimethylglycine, Trimethylaminoacetate, Trimethylammonioacetate, Trimethylglycine |
| Type | |
| Formula | C5H11NO2 |
| Weight | Average: 117.1463 Monoisotopic: 117.078978601 |
| Groups | Approved, Nutraceutical |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Glycinebetaine is a methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels.
Glycinebetaine is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Included within the category of homocystinuria are deficiencies or defects in: 1. cystathionine beta-synthase (CBS), 2. 5,10-methylenetetrahydrofolate reductase (MTHFR), 3. cobalamin cofactor metabolism (cbl).
Glycinebetaine is also used to associated treatment for these conditions: Homocystinuria
How Glycinebetaine works
Glycinebetaine acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria.
Toxicity
In an acute toxicology study in rats, death frequently occurred at doses equal to or greater than 10,000 mg/kg.
Food Interaction
- Take with or without food. Oral betaine powder should be mixed with food or a beverage and then consumed.
Volume of Distribution
V/F = 1.3 l/kg
Elimination Route
After a single oral dose of betaine (50 mg/kg), absorption was rapid (tmax = 0.9 ± 0.3 hours and a Cmax = 0.9 ± 0.2 mM).
Half Life
14 hours
Clearance
84 ml/h/kg
Innovators Monograph
You find simplified version here Glycinebetaine
