Gonak
Gonak Uses, Dosage, Side Effects, Food Interaction and all others data.
Hydroxypropyl methylcellulose belongs to the group of medicines known as artificial tears. It is used to relieve dryness and irritation caused by reduced tear flow. It helps prevent damage to the eye in certain eye diseases. Hydroxypropyl methylcellulose may also be used to moisten hard contact lenses and artificial eyes. In addition, it may be used in certain eye examinations.
Gonak is the most commonly used in hydrophilic matrix fabrication. It allows for controlled release of drug substances, increasing duration of therapeutic effects . The physical characteristics of this drug resemble natural tears, providing lubrication to the ocular surface and maintaining corneal hydration in dry eye syndromes .
Gonak is considered an inert substance as it has no direct pharmacological activity. The viscosity promoting properties of hypromellose prolong the retention time and improve adhesion of synthetic tears to the cornea and conjunctiva. As a result, the tear film breakdown time is prolonged and/or the tear film stability is enhanced. A stable tear film protects the cornea from dryness and epithelial cells .
Gonak is a methyl and hydroxypropyl mixed ether of cellulose. It is utilized as artificial tears to prevent conjunctival and corneal damage due to impaired lacrimal secretions. It is also used as a visco-elastic promoting agent by maintaining a deep, viscous chamber and allowing for easier manipulation, helping the vitreous surface to be pushed back, thus preventing the formation of a postoperative flat chamber .
| Trade Name | Gonak |
| Generic | Hypromellose |
| Hypromellose Other Names | Cellulose hydroxypropyl methyl ether, Hipromelosa, Hydroxypropyl methylcelluloses, Hydroxypropylmethylcellulose, Hypromellose, Hypromelloses |
| Type | Ophthalmic |
| Groups | Approved |
| Therapeutic Class | Drugs for Dry eyes |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Gonak enriched with Carbomer 980 is a long acting eye gel for lubricating the surface of the eye for all patients with ocular discomfort. The slight hypotonicity of the gel is rapidly "neutralised" by the slightly hypertonic tear fluid caused by dry eyes.
Gonak is also used to associated treatment for these conditions: Dry Eyes, Ocular Discomfort, Ocular Irritation
How Gonak works
Promotes corneal wetting by the stabilization and thickening the precorneal tear film and prolonging the tear film breakdown time, which is usually shortened in dry eye conditions. Gonak also acts to lubricate and protect the eye .
The surface active properties of the vehicles found in artificial tears solutions act to stabilize the tear film and increase tear viscosity to prevent delay tear evaporation and delay tear drainage .
In the intact eye, the corneal surface is moistened primarily by the mucin that is produced in the conjunctiva. Mucin is adsorbed on the corneal surface and forms a hydrophilic surface. This creates a moisture barrier. In the typical dry eye, and particularly in case of mucin deficiency, the application of artificial tear fluid is highly recommended. Both its surface activity and its adsorptive capacity make hypromellose optimal for this use. Gonak has a physical-chemical action and leads to, in an aqueous solution, a reduced surface tension as well as an increased level of viscosity. Gonak adheres well to the cornea and conjunctiva and provides ample moisture. Irritation symptoms caused by blinking, which occur in the case of tear fluid deficiency, are therefore decreased and symptoms of epithelial desiccation are also alleviated .
Dosage
Gonak dosage
Instill 1 or 2 drops in the conjunctival sac of the affected eye(s), as needed. The frequency of administration depends on the severity of the condition. On average, one drop is administered 1-3 times daily. If needed, Gonak may be administered more frequently.
Side Effects
Gonak enriched with Carbomer 980 is very well tolerated by users. However, some cases of burning, stinging, allergic reactions or red eyes after instillation have been reported. Transient blurring of vision after administration has also been reported.
Toxicity
LD 50 (Rat): > 5 g/kg .
Gonak is considered low toxicity to non-toxic .
Adverse events may include blurred vision and contact dermatitis . Hypersensitivity and intolerance reactions may occur (for example, eye burning, pain, increased lacrimation, a sensation of foreign body, conjunctival hyperemia, eyelid swelling, pruritus). The stickiness sensation of the eyelids, the decreased sense of smell, photosensitivity .
Precaution
If eye pains, changes in vision, continued redness or irritation of the eye are noticed Gonak must be discontinued and a doctor should be consulted. If Gonak changes color or becomes cloudy, the product should not be used.
Interaction
Gonak can be used in combination with contact lenses. No compatibility study with lens material is available.
Food Interaction
No interactions found.Elimination Route
Not systemically absorbed .
Pregnancy & Breastfeeding use
There is no experience regarding the safety of Gonak in human pregnancy or lactation. Studies in the pediatric population have not been performed.
Contraindication
Hypersensitivity to this drug or to any ingredient in the formulation or component of the container.
Acute Overdose
No case of overdose has been reported.
Storage Condition
Store in a cool dry place, away from light. Keep out of reach of children. Do not touch tip of the tube surface since this may contaminate the gel. After one month of the opening do not use the medicine of tube.
Innovators Monograph
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