Gramicidin A

Gramicidin A Uses, Dosage, Side Effects, Food Interaction and all others data.

Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a β-helix. Active against most Gram-positive bacteria and some Gram-negative organisms, Gramicidin A is used primarily as a topical antibiotic and is also found in Polysporin ophthalmic solution.

Gramicidin is particularly effective against gram-positive bacteria. Because the drug is highly hemolytic, it cannot be administered internally and so is used only on the skin as a lotion or ointment. It is used primarily in the treatment of infected surface wounds, and in eye, nose, and throat infections. It is normally given with two other antibiotics (neomycin and polymixin B) as an ophthalmic solution.

Gramicidin A
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
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Trade Name	Gramicidin A
Generic	Gramicidin D
Gramicidin D Other Names	Bacillus brevis gramicidin D, Gramicidin, Gramicidin A, Gramicidin B, Gramicidin C, Gramicidina, Gramicidine
Type
Formula	C₉₆H₁₃₅N₁₉O₁₆
Weight	Average: 1811.253 Monoisotopic: 1810.033419343
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Gramicidin A is a bactericidal antibiotic used in the treatment of dermatological and ophthalmic infections.

For treatment of skin lesions, surface wounds and eye infections.

Gramicidin A is also used to associated treatment for these conditions: Allergic Skin Reaction, Conjunctivitis, Conjunctivitis allergic, Conjunctivitis infective, Corneal Inflammation, Episcleritis, External ear inflammation, Eye and eyelid infections, Inflammatory Skin Disease, Iridocyclitis, Ocular Inflammation, Otitis Externa, Rosacea Keratitis, Rosacea conjunctivitis, Scleritis, Seborrhoea of the External Ear, Stye, Ulcerative keratitis, Bacterial blepharitis, Infected eczema of the Eyelid, Superficial ocular infections

How Gramicidin A works

Gramicidin A binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization (it acts as a channel). This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death.