Gravidin

Gravidin Uses, Dosage, Side Effects, Food Interaction and all others data.

Gravidin is an orally active gestagen. Gravidin has a pronounced pregnancy maintaining action in castrated animals without producing hormonal side-effects. In the human, premature termination of pregnancy often follows a fall in the levels of placental hormones. Gravidin has been shown to stimulate the placental progesterone production in vitro & to promote the secretion of placental hormones (human chorionic gonadotrophin, human placental lactogen, oestrogens and progesterone) and oxytocinase in patients with pregnancy at risk. In aggrement to this the trophoblastic layers of the placenta show histological signs of activation. Clinical studies have indicated that Gravidin is an effective & safe pregnancy preparation. Administration of Gravidin in combination with bed rest can remove or prevent the threat of abortion in early pregnancy or stop threatened premature labor.

Gravidin is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour. However, with the exception of proven progesterone deficiency, such use is no longer recommended. In threatened miscarriage in progesterone-deficient women a suggested dose is 5 mg three times daily by mouth for 5 to 7 days.

Gravidin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Gravidin
Generic	Allylestrenol
Allylestrenol Other Names	Alilestrenol, Allilestrenolo, Allyl estrenol, Allylestrenol, Allylestrenolum, Allyloestrenol
Type	Injection, Tablet
Formula	C₂₁H₃₂O
Weight	Average: 300.4782 Monoisotopic: 300.245315646
Groups	Experimental
Therapeutic Class	Female Sex hormones
Manufacturer	Zydus Cadila Healthcare Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Gravidin is used for -

- Intra uterine Growth Retardation (IUGR)
- Threatened abortion
- Habitual abortion
- Threatened premature labor
- Failure of nidation

Gravidin is also used to associated treatment for these conditions: Abortions spontaneous, Premature Labour

How Gravidin works

Gravidin is similar in structure and function to progesterone. Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.

Dosage

Gravidin dosage

Gravidin should be taken orally. The dose of the drug depends on the indication.

Intra Uterine Growth Retardation [IUGR]: 1 tablet three times a day at least two months. Reduce the dose if symptoms improve.

Threatened Abortion: 1 tablet thrice daily for 5-7 days. The treatment period may be extended depending on necessity. After symptoms disappear, the dosage should be gradually reduced.

Habitual Abortion: 1 to 2 tablets daily with the confirmation of pregnancy. Administration should be continued until at least one month after the critical period.

Threatened Premature Labour: 40 mg daily until symptoms improve.

Failure of Nidation: 2 - 4 tablets daily from 16th to 26th day of the cycle until conception is achieved.

Side Effects

Gastrointestinal complaints like nausea, vomiting etc. have been reported.

Precaution

Patients with the following conditions should be cautious: Heart disease, congestive heart failure, sick sinus syndrome, coronary artery disease, seizures, epilepsy, renal dysfunction, migraine headaches, or breathing diseases including asthma, emphysema, chronic bronchitis, or COPD, breast-feeding.

Elimination Route

The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.

Pregnancy & Breastfeeding use

Gravidin is extremely safe. Serious adverse reactions have neither been reported in mother. It is free from anti-ovulatory and androgenic properties. Gravidin produces no masculinization of female foetus.

Contraindication

Hypersensitivity; thrombophlebitis; undiagnosed vaginal bleeding, incomplete abortion, hormone-dependent carcinoma, cerebral apoplexy, as a diagnostic test for pregnancy; severe hepatic impairment.

Special Warning

It should not be used for children younger than 16 years old.

Acute Overdose

If you have taken several capsules at once, there is no need for great concern. However, you should consult your doctor. The oily substance in the capsule may cause diarrhea.