Guanethidine Monosulphate Amdipharm

Guanethidine Monosulphate Amdipharm Uses, Dosage, Side Effects, Food Interaction and all others data.

An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem]

High blood pressure can cause the heart and arteries to not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Guanethidine Monosulphate Amdipharm works by decreasing the heart rate and relaxing the blood vessels so that blood can flow more easily through the body, thereby reducing these risks. It is a postganglionic sympathetic nerve terminal blocker that prevents the release of norepinephrine from nerve terminals.

Guanethidine Monosulphate Amdipharm
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Uses during Breastfeeding
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Trade Name	Guanethidine Monosulphate Amdipharm
Availability	Discontinued
Generic	Guanethidine
Guanethidine Other Names	guanéthidine, Guanethidine, guanethidinum, guanetidina
Related Drugs	amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, hydralazine, nifedipine, captopril, enalapril
Type
Formula	C₁₀H₂₂N₄
Weight	Average: 198.3085 Monoisotopic: 198.184446724
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United Kingdom
Last Updated:	September 19, 2023 at 7:00 am

Uses

Guanethidine Monosulphate Amdipharm is an antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension.

For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.

How Guanethidine Monosulphate Amdipharm works

Guanethidine Monosulphate Amdipharm acts at the sympathetic neuroeffector junction by inhibiting or interfering with the release and/or distribution of norepinephrine (NE), rather than acting at the effector cell by inhibiting the association of norepinephrine with its receptors. It is taken up by norepinephrine transporters to be concentrated within the transmitter vesicles in place of NE, leading to gradual depletion of NE stores in the nerve endings. Guanethidine Monosulphate Amdipharm at the nerve terminal blocks the release of noradrenaline in response to an action potential. In contrast to ganglionic blocking agents, Guanethidine Monosulphate Amdipharm suppresses equally the responses mediated by alpha-and beta-adrenergic receptors but does not produce parasympathetic blockade. Since sympathetic blockade results in modest decreases in peripheral resistance and cardiac output, Guanethidine Monosulphate Amdipharm lowers blood pressure in the supine position. It further reduces blood pressure by decreasing the degree of vasoconstriction that normally results from reflex sympathetic nervous activity upon assumption of the upright posture, thus reducing venous return and cardiac output more.