Guanidin
Guanidin Uses, Dosage, Side Effects, Food Interaction and all others data.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Guanidin apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.
| Trade Name | Guanidin |
| Availability | Prescription only |
| Generic | Guanidine |
| Guanidine Other Names | Aminomethanamidine, Guanidin, Guanidine, Imidourea, Iminourea |
| Type | |
| Formula | CH5N3 |
| Weight | Average: 59.0705 Monoisotopic: 59.048347175 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Guanidin is a strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.
For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.
Guanidin is also used to associated treatment for these conditions: Muscle Weakness
Toxicity
LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.
Food Interaction
No interactions found.Guanidin Drug Interaction
Moderate: dicyclomine, dicyclomineUnknown: papain/urea topical, papain/urea topical, amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, fexofenadine / pseudoephedrine, fexofenadine / pseudoephedrine, zolpidem, zolpidem, warfarin, warfarin, lemborexant, lemborexant, meperidine, meperidine, medroxyprogesterone, medroxyprogesterone, fluticasone nasal, fluticasone nasal
Guanidin Disease Interaction
Major: bone marrow suppressionModerate: renal function disorders
Elimination Route
Rapidly absorbed and distributed
Half Life
7-8 hours
Innovators Monograph
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