Guanidine Hcl Uses, Dosage, Side Effects and more

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

Guanidine Hcl apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.

Trade Name	Guanidine Hcl
Availability	Prescription only
Generic	Guanidine
Guanidine Other Names	Aminomethanamidine, Guanidin, Guanidine, Imidourea, Iminourea
Weight	125mg
Type	Oral tablet
Formula	CH₅N₃
Weight	Average: 59.0705 Monoisotopic: 59.048347175
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	January 7, 2025 at 1:49 am

Uses

Guanidine Hcl is a strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.

For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.

Guanidine Hcl is also used to associated treatment for these conditions: Muscle Weakness

Toxicity

LD₅₀ = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.