Gumex

Uses

Camphor is a compound used topically to help relieve pain and also as a topical antiseptic. May also be used in vaporizers to help suppress coughing. This medication should not be swallowed.

Clove oil is used for Bad breath (Halitosis), Tooth decay, Oral thrush, Dental pain, Inflammation of the mouth and pharynx.

Iodine is an ingredient of nutritional supplements that is also used for disinfection.

Investigated for use/treatment in breast disorders (unspecified) and pain (acute or chronic).

Phenol is an antiseptic and disinfectant used in a variety of settings.

Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity.

Potassium Iodide is an oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.

Potassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.

Tannic acid is indicated for cold sores, fever blisters, diaper rash, minor burn or sunburn and prickly heat. Vaginally, tannic acid is used as a douche for leukorrhea. It has been also indicated for sore throat, inflamed tonsils, spongy or receding gums, and acute dermatitis.

Thymol is an essential oil found in various over-the-counter antibacterial and antifungal products.

Gumex is also used to associated treatment for these conditions: Arthritis, Backache, Common Cold, Contusions, Inflammatory Reaction caused by Insect Bites, Joint Pain, Muscle Cramps, Nasal Congestion, Pain caused by Insect Bites, Rash, Skin Irritation, Soreness, Muscle, Sunburn, Swelling caused by Insect Bites, Minor burns, Neck or back pain, Shoulder acheMild pain, ToothacheInfection in minor cuts, scrapes, or burns, Antisepsis, Antimycotic, Prophylaxis of bacterial skin infectionsDermatitis, Dermatitis, Eczematous, Irritation lips, Pruritis of the skin, Psoriasis, Ringworm, Sore Throat, Throat irritation, Moderate, stable PsoriasisAcute radiation sickness, Folate deficiency, Goitre, Hypothyroidism, Iodine Deficiency, Iron Deficiency (ID), Thyroid Cancers, Nutritional supplementation, Skin disinfection, Oral disinfectionArthritis, Backache, Contusions, Joint Diseases, Joint Pain, Muscle Stiffness, Muscle Strain, Muscular Fatigue, Pain, Nerve, Plaque, Dental, Soreness, Muscle, Sprains, Skin disinfection

How Gumex works

The chief constituent present in clove oil is the phenol "eugenol" which is present in amounts up to 85%. Clove oil acts as a germicide to Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa .

Clove oil is thought to inhibit prostaglandin synthesis, thereby reducing painful symptoms .

Eugenol, the main constituent of clove oil is purported to have anticancer action. In one study, eugenol-treated HL-60 cells showed features of apoptosis including DNA fragmentation and formation of DNA ladders in agarose gel electrophoresis. It was observed that eugenol transduced the apoptotic signal via reactive oxygen species (ROS) generation, inducing mitochondrial permeability transition (MPT), decreasing anti-apoptotic protein bcl-2 level, inducing cytochrome c release to the cytosol, and subsequent apoptotic cell death. When taken together, the study showed that ROS plays a critical role in eugenol-induced apoptosis in HL-60, and this is the first report on the mechanism of the anticancer effect of eugenol .

Molecular iodine is known to inhibit the induction and promotion of N-methyl-n-nitrosourea-induced mammary carcinogenesis, to regress 7,12-dimethylbenz(a)anthracene-induced breast tumors in rats.It has also been shown to have beneficial effects in fibrocystic human breast disease.

Phenol is a potent proteolytic agent. Concentrations in the 5% to 7% range dissolve tissue on contact via proteolysis. In high concentrations when injected next to a nerve, phenol produces a chemical neurolysis which is nonselective across nerve fiber size and most prominent on its outer aspect. Local anesthetic effects occur within 5-10 minutes.

Pharmaceutical grade tannic acid is generally considered to be pentadigalloylglucose. It has an astringent effect. When used internally, it dehydrates tissues when cause reduction in secretions. Externally, it works through formation of protective layer of harder and constricted cells. Tannic acid is thought to exert antiviral and antibacterial effects.

Dosage

Gumex dosage

Adult: Should be taken 5 ml Clove oil with 10 ml-15 ml water and gurgle for 30 seconds of morning & bedtime daily.

Children: Should be taken 2.5 ml Clove oil with 10 ml water and gurgle for 30 seconds of morning & bedtime daily. Also undiluted clove oil is used in temporary relief of toothache due to dental cavity. Repeat administration after 20 minutes, then every 2 hours thereafter if necessary.

Side Effects

In concentrated form oil of clove may be irritating to mucosal tissues.

Toxicity

Acute oral toxicity (LD50): 2650 mg/kg [Rat] .

Clove oil is considered safe in small quantities (< 1,500 ppm) as a food additive . the lethal oral dose is 3.75 g per kg body weight in humans .

Contact with skin or soft tissue may cause transient irritation, contact dermatitis, inflammation of the lips, and inflammation or ulceration of the mouth. The eugenol present in clove oil may act as an irritant to skin and mucous membranes; it may also cause hypersensitivity and is reported to inhibit prostaglandin synthesis. Patients may become sensitive to clove oil .

After oral administration of 5-10 ml of clove oil in children below 2 years of age, life-threatening conditions were observed. Adverse effects included coma, acidosis, a generalized seizure, disordered blood clotting, and acute liver damage .

Overdose may lead to CNS depression, urinary abnormalities, anion-gap acidosis, deterioration of liver function, coma, seizure and low blood glucose levels. Treatment should be supportive and symptomatic; there have been reports in the literature that N-acetylcysteine has been successfully used as an antidote .

There are no epidemiological studies of potential adverse human health effects related to exposure to clove leave oil or eugenol from any human exposure scenarios. Nor are there any studies of agricultural use, either in workers or those with bystander exposure or other applications. There are no occupational exposure standards for clove leaf oil or eugenol including OSHA PEL (Permissible Exposure Limit) or AGIHA TLVs (Threshold Limit Value) in air .

Mouse, Subcutaneous, LD50: 0.3-0.35 g/kg. (Duplay and Cazin, 1891; Tollens, 1905). Rat, Subcutaneous, LD50: 0.45. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.53. (Deichmann and Witherup, 1944). Rat, Oral, LD50: 0.65. (Flickinger, 1976). Rat, Cutaneous, LD50: 0.67. (Conning and Hayes, 1970).

LD50 is 2.26 g/Kg in rats.

Volume of Distribution

At I5 min after exposure, the liver contained the highest level of phenol, consisting mainly of free phenol. After 82 minutes post administration, phenol is uniformly distributed in the liver, blood, kidneys, lungs, along with the heart, testes, thymus and the spleen. With the passage of time, the proportion of free to conjugated phenol changed. By 360 minutes most phenol appears in conjugated forms.

Elimination Route

Clove oil is rapidly absorbed through the skin and is used in patented systems for dermal drug delivery to enhance drug uptake from skin patch delivery systems .

Phenol is rapidly absorbed through the skin and into the lungs.

After ingestion it has poor bioavailability, due to large size, high affinity to bound to plasma proteins and low lipid solubility. Its main actions are due to local effects.

Half Life

In a pharmacokinetic study, average half-life values of eugenol in plasma and blood were long (14.0 and 18.3 h, respectively), suggesting a potential accumulation of the drug following repeated administrations .

Clearance

In rabbits, 72% is excreted in the urine, 1% in the feces, 4% in the carcass following sacrifice, and trace amounts were exhaled.

Elimination Route

In a pharmacokinetic study, the metabolism of eugenol (the primary constituent of clove oil) was investigated in healthy male and female volunteers. It was quickly absorbed and metabolized after oral administration and was almost completely excreted in the urine within 24 hours of ingestion .

The kidney is the primary route of elimination of phenol.

Pregnancy & Breastfeeding use

There are no known problems with the use of Clove oil during pregnancy and lactation.

Storage Condition

Store below 30°C. temperature & dry place, protected from light. Keep all medicines out of reach of children.

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