Guneera
Guneera Uses, Dosage, Side Effects, Food Interaction and all others data.
Avobenzone is dibenzoyl methane derivative. It is oil soluble ingredient. Avobenzone has the ability to absorb ultraviolet light over wider range of wavelengths. It is included in many commercially available sunscreens which are used as wide spectrum sunscreens. Avobenzone is very sensitive to light, to increase its stability and duration of action, photostablizers are added in the sunscreen product. Avobenzone has an absorption maximum of 357 nm. Sunscreens containing avobenzone is indicated for providing protection from the sun. In addition to limiting the skin's exposure to the sun, using sunscreen agents may help reduce long-term sun damage such as premature aging of the skin and skin cancer.
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage. It was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun. It is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption. Its use in pharmaceutical and cosmetic formulations is approved by FDA.
Acts as a photoprotective agent that protects the skin by preventing and minimizing the damaging effects of ultraviolet (UV) rays of natural light. The cellular effects of UV irradiation include DNA damage, cell cycle arrest, immunological depression, apoptosis, and transcriptional changes .
Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. Octocrylene is also often combined with avobenzone, another common sunscreen ingredient often appearing on ingredient labels. Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and skin care products, but the concentrations of this ingredient are usually limited to no more than 10 or 12 percent. However, the use of this chemical doesn’t just stop with sunscreen for face and arms, but can extend to a variety of other products, like hair spray, tannin oil, BB cream, conditioner, and CC cream, among others. Octocrylene may cause contact and photocontact allergy.
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays.
Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.
Zinc oxide is used to treat or prevent minor skin irritations such as burns, cuts, poison ivy, poison oak, poison sumac, and diaper rash. It is also used as a sunscreen.
Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations, wounds and haemorrhoids. It also reflects ultraviolet radiation and can be used as a physical sunscreen.
| Trade Name | Guneera |
| Generic | Octinoxate + Octocrylene + Zinc Oxide + Avobenzone + Oxybenzone |
| Weight | 7.5% |
| Type | Gel |
| Therapeutic Class | |
| Manufacturer | Dermajoint India |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Avobenzone is a sunscreen agent found in sunscreens that absorbs UV rays.
Sun protection factor, added in the sunscreen products for its wide spectrum ultraviolet absorption properties.
Octinoxate is a sunscreen agent found in sunscreens that absorbs UV rays.
As an active ingredient in sunscreens and lip balms. Used for protection against damaging effects of sun rays.
Octocrylene is a sunscreen agent found in sunscreens that absorbs UV rays.
In the US, Octocrylene has been evaluated by the FDA and is considered safe for use up to 10% in the formula. Similarly, the EU allows its use up to 10% in a formula while Health Canada allows a maximum use level of 12%.
Oxybenzone is a sunscreen agent found in sunscreens that absorbs UV rays.
Used as an ingredient in sunscreen and other cosmetics.
Zinc Oxide helps to To treat or prevent skin irritations (e.g., burns, bed sore, cuts, poison ivy, diaper rash). Protects chafed skin due to diaper rash and helps seal out wetness.
Guneera is also used to associated treatment for these conditions: SunburnSunburnSunburnSunburnAcute Wounds, Burns first degree, Burns second degree, Dermatitis, Eczematous, Diaper Rash, Herpes Labialis, Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding, Intertrigo, Pain, Pruritus, Sensitive Skin, Skin Irritation, Skin candida, Sunburn, Wounds, Chafing, Damaged skin, Dry, cracked skin, Facial rash, Heat rash, Superficial Wounds, Watery skin lesions, Astringent, Nutritional supplementation
How Guneera works
It blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.
Absorbs UV-B (predominantly) and UV-A rays while accumulating in the outermost layer of the epidermis. Like any other photoprotective agents, octinoxate prevents the damage to cells and deoxyribonucleic acid (DNA) by reducing the p53 protein expression following UV exposure and also increases the skin's tolerability to UV rays .
Octocrylene is an effective oil soluble liquid UV‐B filter. It has excellent dissolving properties for crystalline UV filters. Due to its outstanding photostability it is used as photostabilizer. Conjugated acrylate portion absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths in the range of 280-320 nm which protects the skin from direct DNA damage. The ethylhexanol portion is a fatty alcohol, which functions as an emollient due to it's hydrophobicity.
Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin.
It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.
Dosage
Guneera dosage
Apply thin layer topically every 8 hourly. Change wet and soiled diapers, promptly cleans the diaper area, allow to dry and apply ointment liberally as often as necessary, with each diaper change, especially at bedtime or any time when exposure to wet diapers may be prolonged.
Side Effects
Usually well tolerated. Extremely low frequency of hypersensitivity reaction.
Toxicity
A minimum toxic dose has not been established. Significant toxicity is not expected
Slightly hazardous in case of skin contact, eye contact, ingestion and inhalation. Octinoxate may form reactive singlet oxygen species and induce anti-estrogenic effects . UV-induced molecular breakdown of octinoxate may interfere with cellular processes or induce oxidative damage in human skin . The NOAEL (no observed adverse effect level) is 450 mg/kg bw/day for fertility and reproductive performance, for systemic parental and developmental toxicity in Wistar rats .
Octocrylene is one of those ingredients that can be absorbed into the skin and some studies have shown that it may promote generation of potentially harmful free radicals when exposed to light. Since free radicals can damage DNA, there is concern that this ingredient might have contributed to an increased incidence of melanoma in sunscreen-users compared to non-users.
Acute oral toxicity (LD50): 7950 mg/kg [Mouse].
Precaution
For external use only. Avoid contact with the eyes. Stop use and ask a doctor if condition worsens or does not improve within 7 days. Keep out of the reach of children. If swallowed, get medical help or contact a poison control center right away
Volume of Distribution
Ecamsule is only used topically, it not absorbed.
Intended for local use only, no systemic absorption.
Elimination Route
Can be systemically absorbed after skin application, being found in the deeper layers of the stratum corneum as well as urine, plasma, and breast milk . The mean maximum plasma concentration detected after application of 2mg/cm2 sunscreen was 7ng/mL in women and 16ng/mL in men .
Ecamsule is used topically, it not absorbed or metabolized.
No significant percutaneous absorption from topically applied zinc oxide.
Half Life
Ecamsule is only used topically, it does not have half life
Intended for local use only, no systemic absorption.
Clearance
Ecamsule is used topically, it not absorbed or metabolized.
Intended for local use only, no systemic absorption.
Elimination Route
Can be detected in urine in unchanged form .
Ecamsule is used topically, it not absorbed.
In vivo studies show oxybenzone is abosorbed transdermally (through the skin) and is excreted in the urine.
Intended for local use only, no systemic absorption.
Pregnancy & Breastfeeding use
This medication should be used with precautions only if clearly needed during pregnancy or while breast feeding
Contraindication
Known hypersensitivity to any component of the preparation
Acute Overdose
No overdose related problem is yet reported.
Storage Condition
keep in a cool and dry place, away from light.
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