H Nil Tube

Uses

H Nil Tube Hydrochloride cream, 13.9% is used for the reduction of unwanted facial hair in women. H Nil Tube Hydrochloride has only been studied on the face and adjacent involved areas under the chin of affected individuals. Usage should be limited to these areas of involvement.

H Nil Tube is also used to associated treatment for these conditions: Meningoencephalitic stage Trypanosoma brucei gambiense infection, Hair removal therapy

How H Nil Tube works

H Nil Tube prevents hair growth by inhibiting the anagen phase of hair production. This occurs by eflornithine irreversibly binding (also called suicide inhibition) to ornithine decarboxylase (ODC) and physically preventing the natural substrate ornithine from accessing the active site.

Dosage

H Nil Tube dosage

Adults: Apply a thin layer of H Nil Tube cream, 13.9% to affected areas of the face and adjacent involved areas under the chin and rub in thoroughly. Do not wash treated area for at least 4 hours. Use twice daily at least 8 hours apart or as directed by a physician. The patient should continue to use hair removal techniques as needed in conjunction with H Nil Tube (Wonica should be applied at least 5 minutes after hair removal). Cosmetics or sunscreens may be applied over treated areas after cream has dried.

.Elderly: No apparent differences in safety were observed between older patients and younger patients.

Children: The safety and effectiveness of this product have not been established in pediatric patients less than 12 years of age.

Side Effects

Adverse events were primarily mild in intensity and generally resolved without medical treatment or discontinuation of H Nil Tube. Side effects can include acne, barbae, pseudofolliculitis, stinging skin, headache, burning skin, dry skin, erythema (redness), pruritus (itching), tingling skin, dyspepsia, skin irritation, rash, alopecia, dizziness, folliculitis, hair ingrown, facial edema, anorexia, nausea, asthenia, vertigo.

Precaution

For external use only. Transient stinging or burning may occur when applied to abraded or broken skin.

Interaction

It is not known whether H Nil Tube has any interaction with other topically applied drug products.

Food Interaction

Half Life

8 hours

Elimination Route

Renal

Pregnancy & Breastfeeding use

Pregnancy Category C. It is not known whether or not H Nil Tube Hydrochloride is excreted in human milk. Caution should be exercised when H Nil Tube is administered to a nursing woman.

Contraindication

H Nil Tube is contraindicated in patients with a history of sensitivity to any components of the preparation.

Special Warning

Store at 25°C, excursions permitted to 15°C-30°C. Do not freeze.

Acute Overdose

Overdosage information with H Nil Tube is unavailable. However, if very high topical doses (e.g., multiple tubes per day) or oral ingestion has been encountered (a 30 gm tube contains 4.2 gm of H Nil Tube Hydrochloride), the patient should be monitored, and appropriate supportive measures should be administered as necessary.

Storage Condition

Store at 25°C, excursions permitted to 15°C-30°C. Do not freeze.

Innovators Monograph

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