H.P. Acthar

H.P. Acthar Uses, Dosage, Side Effects, Food Interaction and all others data.

H.P. Acthar (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.

H.P. Acthar acts through the stimulation of cell surface ACTH receptors, which are primarily located on the adrenocortical cells. H.P. Acthar stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). H.P. Acthar is also related to the circadian rhythm in many organisms.

H.P. Acthar
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	H.P. Acthar
Availability	Prescription only
Generic	Corticotropin
Corticotropin Other Names	ACTH, Adrenocorticotrophin, Adrenocorticotropic hormone, Corticotrophin, Corticotropin, Cortigel, H.P. acthar gel
Related Drugs	Humira, Cosentyx, Gilenya, Tysabri, Vumerity, aspirin, prednisone, ibuprofen, meloxicam, hydroxyzine
Type	Injection
Formula	C₂₀₇H₃₀₈N₅₆O₅₈S
Weight	4541.0658 Da
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

H.P. Acthar is a diagnostic agent used in the screening of patients presumed to have adrenocortical insufficiency.

For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.

H.P. Acthar is also used to associated treatment for these conditions: Ankylosing Spondylitis (AS), Anterior Segment Inflammation, Chorioretinitis, Choroiditis, Corneal Inflammation, Erythema multiforme, Gouty Arthritis, Infantile Spasms (IS), Iridocyclitis, Iritis, Multiple sclerosis exacerbation, Nephrotic Syndrome, Optic Neuritis, Polymyositis, Psoriatic Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Serum Sickness, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus (SLE), Symptomatic Sarcoidosis

How H.P. Acthar works

As a diagnostic aid (adrenocortical function), corticotropin combines with a specific receptor on the adrenal cell plasma membrane. In patients with normal adrenocortical function, it stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of cholesterol within the mitochondria. H.P. Acthar does not significantly increase serum cortisol concentrations in patients with primary adrenocortical insufficiency (Addison's disease). The mechanism of action of corticotropin in the treatment of infantile myoclonic seizures is unknown.

Food Interaction

No interactions found.

H.P. Acthar Hypertension interaction

[Major] Adrenocorticotropic agents may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure.

Therapy with these agents, particularly if intended for longer than brief periods, should be administered cautiously in patients with preexisting fluid retention or conditions that may be aggravated by these effects.

Dietary sodium restriction and potassium supplementation may be advisable.

The manufacturers consider the use of adrenocorticotropic agents to be contraindicated in patients with congestive heart failure or uncontrolled hypertension.

H.P. Acthar Drug Interaction

Moderate: insulin lispro, insulin lispro, liraglutide, liraglutideUnknown: duloxetine, duloxetine, gabapentin, gabapentin, esomeprazole, esomeprazole, acetaminophen, acetaminophen, alfuzosin, alfuzosin, ergocalciferol, ergocalciferol, cholecalciferol, cholecalciferol, rivaroxaban, rivaroxaban

H.P. Acthar Disease Interaction

Major: (+) tuberculin test, adrenal insufficiency, electrolyte imbalance, fluid retention, GI perforation, hyperadrenocorticism, infections, ocular herpes simplex, osteoporosis, PUD, scleroderma, vaccinationModerate: cirrhosis, depression/psychoses, diabetes, elevated IOP, hypothyroidism, myasthenia gravis, myopathy, thromboembolism

Elimination Route

H.P. Acthar is rapidly absorbed following intramuscular administration; the repository dosage form is slowly absorbed over approximately 8 to 16 hours.