Halox F

Halox F Uses, Dosage, Side Effects, Food Interaction and all others data.

Fusidic acid is an antimicrobial agent that inhibits bacterial protein synthesis. Fusidic acid interferes with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes. Fusidic acid is active against a wide range of gram-positive organisms. The sustained release formulation ensures prolonged contact with the conjunctival sac. Fusidic acid penetrates well into the aqueous humor.

Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection.

Halometasone is a topical corticosteroid with glucocorticoid activity. It exhibits anti-inflammatory and immunosuppressive effects by inhibiting the release of various cytokines.

Halox F
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Halox F
Generic	Halometasone + Fusidic Acid
Weight	0.05%
Type	Cream
Therapeutic Class
Manufacturer	Ranbaxy Laboratories (sun Pharma)
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Fusidic Acid is used for the topical treatment of superficial bacterial infections of the eye and its adnexa. These may include - bacterial conjunctivitis, blepharoconjunctivitis, blepharitis, sty and keratitis. It may also be used for the management of corneal and conjunctival abrasions and foreign body injuries.

Corticosteriod-responsive dermatoses, Dermatitis

Halox F is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Eye and eyelid infections, Fungal skin infection, Skin Infections caused by Corynebacterium minutissimum infection, Skin Infections caused by Staphylococcus Aureus, Skin Infections caused by Streptococcus Infection, Skin Infections, Bacterial, Stye, Cutaneous dermatophyte infection, Eczematous rash, Mild Atopic dermatitis, Mild Dermatitis caused by Staphylococcus aureusis, Moderate Atopic dermatitis, Moderate Dermatitis caused by Staphylococcus aureusis, Ocular bacterial infections, Susceptible Bacterial InfectionsCorticosteroid responsive, Inflammatory Dermatosis

How Halox F works

Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.

Dosage

Halox F dosage

Adults and children (≥ 2 years): Instill one drop in the affected eye(s) twice daily for 7 days. Treatment should be continued for at least 48 hours after the eye returns to normal.

Apply as a 0.05% cream or ointment on affected areas.

Side Effects

Fusidic acid is generally associated with very few adverse effects. The most frequently reported treatment-related side-effect is slight stinging or irritation.

Bone disorders; muscle fractures; muscle wasting; Na depletion; hyperglycaemia; impaired tissue repair; susceptibility to infections; menstrual irregularities; hyperhydrosis; skin thinning.

Precaution

For ophthalmic use only
To avoid possible contamination of the drops, do not touch the tube nozzle or to any surface
Do not wear contact lenses during the treatment
If more than one topical eye drug is being used, the drugs should be administered at least five (5) minutes interval between applications

Risk of systemic absorption when applied to large areas, broken skin or under occlusive dressings.

Interaction

Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.

Elimination Route

Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Half Life

Approximately 5 to 6 hours in adults.

Pregnancy & Breastfeeding use

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Fusidic acid should be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not clear if enough medication from the eye drop would pass into breast milk. Caution should be exercised while giving this eye drops to a nursing mother

Pregnancy category- not classified

Contraindication

Fusidic acid viscous eye drops is contraindicated in patients who are hypersensitive to any component of Fusidic Acid (Eye Drops).

Hypersensitivity. Not to be applied with an occlusive dressing and to large areas of the body. Rosaceae, leg ulcers, long-term topical treatment esp in child.