HandiSafe

Uses

For the disinfection of clean and intact skin. For pre-operative surgical hand disinfection, hand disinfection on the ward prior to aseptic procedures or after handling contaminated materials. For disinfection of the patients’ skin prior to surgery or other invasive procedures

HandiSafe is also used to associated treatment for these conditions: Ear infection bacterial, Seborrheic Keratosis (SK), Excess ear wax, Superficial skin infections

How HandiSafe works

The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids in vivo . The oxidizing radical as the ferryl radical induces DNA oxidation .

Dosage

HandiSafe dosage

As required

Side Effects

Irritating burns on the skin and mucous membranes (strong solutions); reversible hypertrophy of the papillae of the tongue with continued use as mouthwash; gas embolism, rupture of the colon, proctitis, ulcerative colitis and gangrene of the intestines have occurred following colonic lavage with hydrogen peroxide solution.

Toxicity

Oral LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig. LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours .

Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans. Inhalation of highly concentrated vapours causes extreme irritation of nose and throat .

Hydrogen peroxide has no known carcinogenic potential. It was shown to be mutagenic to bacteria (Salmonella typhimurium) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli . It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro .

Precaution

Glycerol is for external use only. When using this product do not get into eyes. Do not use on deep or puncture wounds, animal bites & serious burns.

Before using hydrogen peroxide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Interaction

If you are using this product under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Volume of Distribution

Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney .

Elimination Route

It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue .

Pregnancy & Breastfeeding use

Hydrogen peroxide is safe to use during pregnancy. It is unlikely that this product passes into breast milk. Consult your doctor before breast-feeding.

Contraindication

Usually well tolerated. People with prior history of sensitivity or allergic reaction to this product or any of its ingredients should not use it.

Inj or instillation of hydrogen peroxide into closed body cavities.

Storage Condition

Should be stored in cool and dry place

Innovators Monograph

You find simplified version here HandiSafe