Hansaplast (ANESTHETICS)
Hansaplast (ANESTHETICS) Uses, Dosage, Side Effects, Food Interaction and all others data.
Although the precise mechanism of action of Hansaplast (ANESTHETICS) is not fully understood, current evidence suggests that Hansaplast (ANESTHETICS) exerts an analgesic effect by depleting and preventing reaccumulation of Substance P in peripheral sensory neurons. Substance P is thought to be the principal chemomediator of pain impulses from the periphery to the central nervous system.
Hansaplast (ANESTHETICS) is a TRPV1 receptor agonist. TRPV1 is a trans-membrane receptor-ion channel complex activated by temperatures higher than 43 degrees Celsius, pH lower than 6, and endogenous lipids. When activated by a combination of these factors, the channel can transiently open and initiate depolarization due to the influx of calcium and sodium ions. Because TRPV1 is commonly expressed in A-delta and mostly C fibers, depolarization results in action potentials which send impulses to the brain and spinal cord. These impulses result in capsaicin effects of warming, tingling, itching, stinging, or burning. Hansaplast (ANESTHETICS) also causes more persistent activation of these receptors compared to the environmental agonists, resulting in a loss of response to many sensory stimuli, described as "defunctionalization". Hansaplast (ANESTHETICS) is associated with many enzymatic, cytoskeletal, and osmotic changes, as well as disruption of mitochondrial respiration, impairing nociceptor function for extended periods of time.
Trade Name | Hansaplast (ANESTHETICS) |
Generic | Capsaicin |
Capsaicin Other Names | Capsaicin, Capsaicina, Isodecenoic acid vanillylamide |
Type | |
Formula | C18H27NO3 |
Weight | Average: 305.4119 Monoisotopic: 305.199093735 |
Groups | Approved |
Therapeutic Class | Topical Analgesics, Topical anti-inflammatory preparations |
Manufacturer | |
Available Country | Portugal |
Last Updated: | September 19, 2023 at 7:00 am |
![Hansaplast (ANESTHETICS) Hansaplast (ANESTHETICS)](https://www.medicinesfaq.com/media/png/hansaplast-anesthetics.png)
Uses
Hansaplast (ANESTHETICS) is indicatd for- Rheumatoid arthritis, Osteoarthritis, Pain due to diabetic neuropathy, Joint pain, Post-herpetic neuralgia, Post-surgical neuropathic pain, Nerve Pain, Back pain, Muscle pain, Fibromyalgia, Bursitis, Pruritis (itching)
Hansaplast (ANESTHETICS) is also used to associated treatment for these conditions: Arthritis, Back Pain Lower Back, Backache, Bursitis, Contusions, Inflammatory Reaction caused by Rheumatism, Muscle Cramps, Musculoskeletal Pain, Osteoarthritis (OA), Periarthritis, Post-Herpetic Neuralgia (PHN), Rheumatic Pain, Soft Tissue Injury, Tendinitis, Acute nonspecific tenosynovitis
How Hansaplast (ANESTHETICS) works
Hansaplast (ANESTHETICS) has been shown to reduce the amount of substance P associated with inflammation - however this is not believed to be its main mechanism in the relief of pain . Hansaplast (ANESTHETICS)'s mechanism of action is attributed to "defunctionalization" of nociceptor fibers by inducing a topical hypersensitivity reaction on the skin. This alteration in pain mechanisms is due to many of the following: temporary loss of membrane potential, inability to transport neurotrophic factors leading to altered phenotype, and reversible retraction of epidermal and dermal nerve fiber terminals.
Dosage
Hansaplast (ANESTHETICS) dosage
18 years of age and older:Apply a thin film of Hansaplast (ANESTHETICS) cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.
Side Effects
Hansaplast (ANESTHETICS) may cause transient burning on application. This burning is observed more frequently when the application schedules are more than 3-4 times daily. The burning can be enhanced if too much cream is used and if it is applied just before or after a bath or shower.
Toxicity
Acute oral LD50 and dermal LD50 in mouse are 47.2 mg/kg and >512 mg/kg, respectively . Hansaplast (ANESTHETICS) is shown to be mutagenic for bacteria and yeast .
Hansaplast (ANESTHETICS) can cause serious irritation, conjunctivitis and lacrimation via contact with eyes. It induces a burning sensation and pain in case of contact with eyes and skin. As it is also irritating to the respiratory system, it causes lung irritation and coughing as well as bronchoconstriction. Other respiratory effects include laryngospasm, swelling of the larynx and lungs, chemical pneumonitis,respiratory arrest and central nervous system effects such as convulsions and excitement . In case of ingestion, gastrointestinal tract irritation may be observed along with a sensation of warmth or painful burning . Symptoms of systemic toxicity include disorientation, fear, loss of body motor control including diminished hand-eye coordination, hyperventilation, tachycardia, and pulmonary oedema . Careful early decontamination is recommended and medical intervention should be initiated for any life-threatening symptoms. In case of contact, individual must be removed from the source of exposure and the contacted skin and mucous membranes should be thoroughly washed with copious amounts of water .
Precaution
Hansaplast (ANESTHETICS) cream should not be applied to broken or irritated skin. Applied area should not be tightly bandaged. Do not get on mucous membranes and into eyes or on contact lenses. If this occurs, rinse the affected area thoroughly with water. Do not apply the cream on the heat treated area as this may increase the burning sensation. In case of accidental ingestion, seek physician advice immediately.
Food Interaction
No interactions found.Elimination Route
Oral: Following oral administration, capsaicin may be absorbed by a nonactive process from the stomach and whole intestine with an extent of absorption ranging between 50 and 90%, depending on the animal . The peak blood concentration can be reached within 1 hour following administration . Hansaplast (ANESTHETICS) may undergo minor metabolism in the small intestine epithelial cells post-absorption from the stomach into the small intestines. While oral pharmacokinetics information in humans is limited, ingestion of equipotent dose of 26.6 mg of pure capsaicin, capsaicin was detected in the plasma after 10 minutes and the peak plasma concentration of 2.47 ± 0.13 ng/ml was reached at 47.1 ± 2.0 minutes .
Systemic: Following intravenous or subcutaneous administration in animals, the concentrations in the brain and spinal cord were approximately 5-fold higher than that in blood and the concentration in the liver was approximately 3-fold higher than that in blood .
Topical: Topical capsaicin in humans is rapidly and well absorbed through the skin, however systemic absorption following topical or transdermal administration is unlikely . For patients receiving the topical patch containing 179 mg of capsaicin, a population analysis was performed and plasma concentrations of capsaicin were fitted using a one-compartment model with first-order absorption and linear elimination. The mean peak plasma concentration was 1.86 ng/mL but the maximum value observed in any patient was 17.8 ng/mL .
Half Life
Following oral ingestion of equipotent dose of 26.6 mg of pure capsaicin, the half life was approximately 24.9 ± 5.0 min . Following topical application of 3% solution of capsaicin, the half-life of capsaicin was approximately 24 h . The mean population elimination half-life was 1.64 h following application of a topical patch containing 179 mg of capsaicin .
Elimination Route
It is proposed that capsaicin mainly undergoes renal excretion, as both the unchanged and glucuronide form. A small fraction of unchanged compound is excreted in the feces and urine. In vivo animal studies demonstrates that less than 10 % of an administered dose was found in faces after 48 h .
Pregnancy & Breastfeeding use
The safety of Hansaplast (ANESTHETICS) during pregnancy or lactation has not been established in either humans or animals.
Contraindication
Hansaplast (ANESTHETICS) cream is contraindicated on broken or irritated skin. It is also contraindicated in patients with known hypersensitivity to capsaicin or any of the excipients used in this product.
Acute Overdose
Sufficient information on overdose of Hansaplast (ANESTHETICS) is not available.
Storage Condition
Keep at cool and dry place, away form light. Keep out of the reach of children.
Innovators Monograph
You find simplified version here Hansaplast (ANESTHETICS)
Hansaplast (ANESTHETICS) contains Capsaicin see full prescribing information from innovator Hansaplast (ANESTHETICS) Monograph, Hansaplast (ANESTHETICS) MSDS, Hansaplast (ANESTHETICS) FDA label