Hasvit Forte

Uses

Calcium Pantothenate is used as a calcium supplement, dietary supplements, burning feet syndrome, greying hair, peripheral neuritis, muscular cramps.

Magnesium oxide is a compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.

Indicated for over-the-counter use as a supplement for cardiovascular and neuromuscular health, and as an antacid for relief of acid indigestion and upset stomach.

Methionine is an amino acid commonly found as a component in total parenteral nutrition.

Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.

Zinc Oxide helps to To treat or prevent skin irritations (e.g., burns, bed sore, cuts, poison ivy, diaper rash). Protects chafed skin due to diaper rash and helps seal out wetness.

Hasvit Forte is also used to associated treatment for these conditions: Acid indigestion, Heartburn, Bowel preparation therapy, Nutritional supplementationHepatic Encephalopathy (HE), Amino acid supplementationAcute Wounds, Burns first degree, Burns second degree, Dermatitis, Eczematous, Diaper Rash, Herpes Labialis, Injuries to the Nipple (Fissures and Cracks) Resulting Breastfeeding, Intertrigo, Pain, Pruritus, Sensitive Skin, Skin Irritation, Skin candida, Sunburn, Wounds, Chafing, Damaged skin, Dry, cracked skin, Facial rash, Heat rash, Superficial Wounds, Watery skin lesions, Astringent, Nutritional supplementation

How Hasvit Forte works

The term "Milk of Magnesia" was first used to describe a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium supplements have also been shown to reduce platelet aggregation by inhibiting in the influx of calcium, a crucial component of platelet aggregation.

The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability.

It acts by providing a physical barrier to prevent skin irritation and help heal damaged skin.

Dosage

Hasvit Forte dosage

Slow intravenous or deep intramuscularas required or as directed by physician.

Apply thin layer topically every 8 hourly. Change wet and soiled diapers, promptly cleans the diaper area, allow to dry and apply ointment liberally as often as necessary, with each diaper change, especially at bedtime or any time when exposure to wet diapers may be prolonged.

Side Effects

Mild gastrointestinal disturbances, bradicardia, arrythmia and irritation after IV injection

Usually well tolerated. Extremely low frequency of hypersensitivity reaction.

Toxicity

Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.

Acute oral toxicity (LD50): 7950 mg/kg [Mouse].

Precaution

Renal impairment, sarcoidosis, concurrent administration of thiazide diuretics may increase the risk of hypercalcaemia.

For external use only. Avoid contact with the eyes. Stop use and ask a doctor if condition worsens or does not improve within 7 days. Keep out of the reach of children. If swallowed, get medical help or contact a poison control center right away

Interaction

There are no known drug interactions and none well documented.

Volume of Distribution

Intended for local use only, no systemic absorption.

Elimination Route

Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.

No significant percutaneous absorption from topically applied zinc oxide.

Half Life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Elimination Route

Intended for local use only, no systemic absorption.

Pregnancy & Breastfeeding use

Pregnancy Category-C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

This medication should be used with precautions only if clearly needed during pregnancy or while breast feeding

Contraindication

Contraindicated in patients with hypercalcaemia, hypercalciuria.

Known hypersensitivity to any component of the preparation

Acute Overdose

No overdose related problem is yet reported.

Storage Condition

keep in a cool and dry place, away from light.

Innovators Monograph

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