Heminevrin
Heminevrin Uses, Dosage, Side Effects, Food Interaction and all others data.
Heminevrin is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.
Trade Name | Heminevrin |
Generic | Clomethiazole |
Clomethiazole Other Names | Clomethiazole, Clomethiazolum, Clometiazol |
Type | |
Formula | C6H8ClNS |
Weight | Average: 161.65 Monoisotopic: 161.0065981 |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | Czech Republic, Hungary, Iceland, Norway, Oman, Russia, Sweden |
Last Updated: | September 19, 2023 at 7:00 am |
![Heminevrin Heminevrin](https://www.medicinesfaq.com/media/png/heminevrin.png)
Uses
Investigated for use/treatment in strokes.
How Heminevrin works
clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system
Innovators Monograph
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