Heminevrin / Clomethiazole
Heminevrin / Clomethiazole Uses, Dosage, Side Effects, Food Interaction and all others data.
Heminevrin / Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.
Trade Name | Heminevrin / Clomethiazole |
Generic | Clomethiazole |
Clomethiazole Other Names | Clomethiazole, Clomethiazolum, Clometiazol |
Type | Capsule |
Formula | C6H8ClNS |
Weight | Average: 161.65 Monoisotopic: 161.0065981 |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | Cheplapharm Arzneimittel GmbH |
Available Country | United Kingdom |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in strokes.
How Heminevrin / Clomethiazole works
clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system
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