Hexachlorophene
Hexachlorophene Uses, Dosage, Side Effects, Food Interaction and all others data.
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
| Trade Name | Hexachlorophene |
| Generic | Hexachlorophene |
| Hexachlorophene Other Names | hexachlorophène, Hexachlorophene, Hexachlorophenum, Hexaclorofeno |
| Type | Topical application |
| Formula | C13H6Cl6O2 |
| Weight | Average: 406.904 Monoisotopic: 403.849895678 |
| Protein binding | 92% |
| Groups | Approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Hexachlorophene is a chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser.
For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Hexachlorophene is also used to associated treatment for these conditions: Bacterial Infections, Antibiotic pre-surgical prophylaxis, Prophylaxis of bacterial skin infections
How Hexachlorophene works
The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Toxicity
Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Food Interaction
No interactions found.Elimination Route
Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Innovators Monograph
You find simplified version here Hexachlorophene
