Hexaclox

Hexaclox Uses, Dosage, Side Effects, Food Interaction and all others data.

Cloxacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.

Hexaclox
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Hexaclox
Generic	Cloxacillin + Amoxycillin / Amoxicillin
Weight	250mg
Type	Capsule
Therapeutic Class
Manufacturer	Micro Labs
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Cloxacillin is used for the treatment of infections caused by Grampositive organisms including infections caused by β-lactamase producing Staphylococci such as :

Skin and soft tissue infections : Boils, Abscesses, Carbuncles, Furunculosis, Cellulitis, Infected wounds, Infected burns, Otitis media and externa, Protection of skin graft and Skin infections like ulcer, eczema, acne, etc.
Respiratory tract infections : Pneumonia, Lung abscess, Empyema, Sinusitis, Pharyngitis and Tonsillitis.
Other infections caused by sensitive organisms : Osteomyelitis, Enteritis, Endocarditis, Urinary tract infection, Meningitis and Septicaemia.

Hexaclox is also used to associated treatment for these conditions: Infection caused by staphylococci, Infections caused by penicillinase-producing staphylococci, Pneumococcal Infection, Streptococcal Infections

How Hexaclox works

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.

Dosage

Hexaclox dosage

Upper Respiratory Tract Infection (Adult):

Usual Dose: 250 mg orally every 6 hours for 7 to 14 days, depending on the nature and severity of the infection.
Maximum dose: 4 g/day.

Upper Respiratory Tract Infection (Pediatric):

Usual Dose: The safety and efficacy of cloxacillin in children < 1 year have not been established.
≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours.
Maximum dose: 4 g/day.

Pneumonia(Adult):

Usual Dose: 500 mg orally every 6 hours for up to 21 days, depending on the nature and severity of the infection.
Maximum dose: 4 g/day.

Pneumonia(Pediatric):

Usual Dose: The safety and efficacy of cloxacillin in children < 1 year have not been established.
≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours.
Maximum dose: 4 g/day.

Skin and Structure Infection(Adult):

Usual Dose: 500 mg orally every 6 hours for 7 days, or until 3 days after acute inflammation resolves, depending on the nature and severity of the infection.
Maximum dose: 4 g/day.

Skin and Structure Infection (Pediatric):

Usual Dose: The safety and efficacy of cloxacillin in children < 1 year have not been established.
≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours.
Maximum dose: 4 g/day.

Cystitis:

Usual Adult Dose: 250 mg orally every 6 hours for 3 to 7 days, depending on the nature and severity of the infection. Cloxacillin is rarely indicated for the treatment of cystitis.
Maximum dose: 4 g/day.

Side Effects

Common side effects are skin rash, transient diarrhoea, nausea, heartburn, pruritus and disturbance of blood electrolyte. Rarely anaphylactic shock.

Toxicity

Oral LD₅₀ in rat and mouse is 5000 mg/kg. Intravenous LD₅₀ in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.

Precaution

Cloxacillin should be given with caution to patients with known history of allergy.

Interaction

May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time with anticoagulants. Increased serum concentrations with probenecid. Tetracycline may antagonise the bactericidal effect of cloxacillin.

Elimination Route

Well absorbed from the gastrointestinal tract.

Pregnancy & Breastfeeding use

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).