Hexobarbitone
Hexobarbitone Uses, Dosage, Side Effects, Food Interaction and all others data.
A barbiturate that is effective as a hypnotic and sedative.
Hexobarbitone is a barbiturate derivative having hypnotic and sedative effects. It was subsequently used in the 1940s and 1950s as an anesthetic for surgery. Furthermore, the agent also demonstrates a fairly quick onset of action that also possesses a short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine, usually thiopental would be the barbiturate of choice for this application these days.
| Trade Name | Hexobarbitone |
| Generic | Hexobarbital |
| Hexobarbital Other Names | Hexobarbital, Hexobarbitone, Methexenyl, Methylhexabital |
| Type | |
| Formula | C12H16N2O3 |
| Weight | Average: 236.267 Monoisotopic: 236.116092388 |
| Protein binding | 25% |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli.
How Hexobarbitone works
Hexobarbitone binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Toxicity
Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Innovators Monograph
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