Hidroxiestilbamidina

Hidroxiestilbamidina Uses, Dosage, Side Effects, Food Interaction and all others data.

Hidroxiestilbamidina isethionate is used in the therapy of some patients with nonprogressive blastomycosis of the skin, and pulmonary or systemic blastomycosis in children, with fewer side effects than amphotericin B. Hidroxiestilbamidina isethionate is also used in pathology for diagnostic purposes.

Hidroxiestilbamidina isethionate is a member of the diamidines, a large family of biochemially and pharmacologically interesting compounds. It has a rather unusual combination of properties, exhibiting antitrypanosomal, antimaliarial, antifungal and carcinostatic activities. It also appears to act as an immunosuppressant. This drug may be used in the treatment of blastomycosis, a disease cased by the dimorphic fungus or mold called Blastomyces dermatitids. Blastomycosis is a pulmonary infection that can lead to fever, cough and (rarely) symptoms similar to tuberculosis. Hidroxiestilbamidina has largely been replaced with amphotericin B.

Table Of contents

• Hidroxiestilbamidina
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Hidroxiestilbamidina
Generic	Hydroxystilbamidine
Hydroxystilbamidine Other Names	Hidroxiestilbamidina, Hydroxystilbamidine, Hydroxystilbamidinum, Idrossistilbamidina, Oxistilbamidinum
Type
Formula	C16H16N4O
Weight	Average: 280.331 Monoisotopic: 280.132411151
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used in the treatment of nonprogressive blastomycosis of the skin and other mycoses.

How Hidroxiestilbamidina works

Hidroxiestilbamidina isethionate (HSB) acts on extracellular DNA and lysosomes. In Trypanosomes there is extensive and selective binding of HSB to the kinetoplastic DNA. This inhibits cell division and reproduction. In yeast there is evidence of binding to extranuclear DNA causing numerous mutations. HSB is also taken up in the lysosomes and leads to a significant increase in the number of lysosome-like bodies and secretion granules in trypanosomal organisms. HSB may also stabilize lysosomal membranes. HSB has also been found to bind RNA and is a powerful inhibitor of cellular ribonucleases.

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