Higlo
Higlo Uses, Dosage, Side Effects, Food Interaction and all others data.
Calcium is used to prevent or treat negative calcium balance. It also helps facilitate nerve and muscle performance as well as normal cardiac function. Bone mineral component; cofoactor in enzymatic reactions, essential for neurotransmission, muscle contraction, and many signal transduction pathways.
A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.
L-Methionine is a principle supplier of sulfur which prevents disorders of the hair, skin and nails; helps lower cholesterol levels by increasing the liver's production of lecithin; reduces liver fat and protects the kidneys; a natural chelating agent for heavy metals; regulates the formation of ammonia and creates ammonia-free urine which reduces bladder irritation; influences hair follicles and promotes hair growth. L-methionine may protect against the toxic effects of hepatotoxins, such as acetaminophen. Methionine may have antioxidant activity.
| Trade Name | Higlo |
| Generic | Vitamin B9 / Folic Acid / Folate + Elemental Zinc + Elemental Copper + Vitamin B7 / Biotin / Vitamin H + Methionine + Calcium Pantothenate + Sodium Selenite + N Acetylcarnosine |
| Weight | 3mg |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | Bioss Health Care |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Calcium Pantothenate is used as a calcium supplement, dietary supplements, burning feet syndrome, greying hair, peripheral neuritis, muscular cramps.
Methionine is an amino acid commonly found as a component in total parenteral nutrition.
Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
Higlo is also used to associated treatment for these conditions: Hepatic Encephalopathy (HE), Amino acid supplementation
How Higlo works
The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability.
Dosage
Higlo dosage
Slow intravenous or deep intramuscularas required or as directed by physician.
Side Effects
Mild gastrointestinal disturbances, bradicardia, arrythmia and irritation after IV injection
Toxicity
Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.
Precaution
Renal impairment, sarcoidosis, concurrent administration of thiazide diuretics may increase the risk of hypercalcaemia.
Interaction
There are no known drug interactions and none well documented.
Elimination Route
Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.
Pregnancy & Breastfeeding use
Pregnancy Category-C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks
Contraindication
Contraindicated in patients with hypercalcaemia, hypercalciuria.
Innovators Monograph
You find simplified version here Higlo
