Hoestbruisten HTP Acetylcysteïne

Hoestbruisten HTP Acetylcysteïne Uses, Dosage, Side Effects, Food Interaction and all others data.

Hoestbruisten HTP Acetylcysteïne has a mucolytic activity through its free sulfhydryl group. It acts directly on the mucoproteins to open the disulfide bonds and thus lowers the viscosity of the mucous and facilitates its removal by the muco-cillary action and expectoration. Hoestbruisten HTP Acetylcysteïne improves the phagocytic capacity of the alveolar macrophages, thus protecting lungs from a variety of insults. Hoestbruisten HTP Acetylcysteïne is a precursor to glutathione, the most important intra & extra-cellular antioxidant (the safest & most convenient)

Hoestbruisten HTP Acetylcysteïne is indicated for mucolytic therapy and in the management of acetaminophen overdose. It has a short duration of action as it is given every 1-8 hours depending on route of administration, and has a wide therapeutic window. Patients should be counselled regarding diluting oral solutions in cola for taste masking, the risk of hypersensitivity, and the risk of upper gastrointestinal hemorrhage.

Trade Name Hoestbruisten HTP Acetylcysteïne
Availability Rx and/or OTC
Generic Acetylcysteine
Acetylcysteine Other Names (R)-mercapturic acid, Acetilcisteina, Acetylcysteine, Acetylcysteinum, L-acetylcysteine, Mercapturic acid, N-acetylcysteine
Related Drugs biotin, Vitamin C, ascorbic acid, multivitamin, Zinc, Fish Oil, Mucinex DM, Robitussin Cough + Chest Congestion DM, dextromethorphan / guaifenesin, Tussin DM
Type
Formula C5H9NO3S
Weight Average: 163.195
Monoisotopic: 163.030313849
Protein binding

Acetylcysteine is 66-97% protein bound in serum, usually to albumin.

Groups Approved, Investigational
Therapeutic Class Antidote preparations, Cough expectorants & mucolytics
Manufacturer
Available Country Netherlands
Last Updated: September 19, 2023 at 7:00 am
Hoestbruisten HTP Acetylcysteïne
Hoestbruisten HTP Acetylcysteïne

Uses

Hoestbruisten HTP Acetylcysteïne is used for an adjunctive treatment for patients with abnormal, viscid or inspissated mucus secretions associated with conditions such as-

Acute and chronic bronchopulmonary disorders (e.g. pneumonia, bronchitis, emphysema, tracheobronchitis, chronic asthmatic bronchitis, tuberculosis, bronchiectasis, primary amyloidosis of the lung) Atelectasis caused by mucus obstruction Pulmonary complications of cystic fibrosis Pulmonary complications of thoracic and cardiovascular surgery Post-traumatic chest conditions.

It is effective in all respiratory airways disease causing formation of a dense secretion that cannot be or can only partially be expectorated such as acute and chronic bronchitis, laryngitis, sinusitis, tracheitis, infuenza & bronchial asthma. Hoestbruisten HTP Acetylcysteïne is also used for the treatment of Paracetamol overdose. Treatment option is optimal if given within 8 hours of Paracetamol ingestion.

Hoestbruisten HTP Acetylcysteïne is also used to associated treatment for these conditions: Acetaminophen Overdose, Chronic Rhinitis, Corneal Diseases, Corneal ulceration, Crusting Rhinitis, Keratopathy, Rhinitis, Sinusitis, Vasomotor Rhinitis, Acute Rhinitis, Subacute Rhinitis, Airway secretion clearance therapy

How Hoestbruisten HTP Acetylcysteïne works

A number of possible mechanisms for the mucolytic activity of acetylcysteine have been proposed. Hoestbruisten HTP Acetylcysteïne's sulfhydryl groups may hydrolize disulfide bonds within mucin, breaking down the oligomers, and making the mucin less viscous. Hoestbruisten HTP Acetylcysteïne has also been shown to reduce mucin secretion in rat models. It is an antioxidant in its own right but is also deacetylated to cysteine, which participates in the synthesis of the antioxidant glutathione. The antioxidant activity may also alter intracellular redox reactions, decreasing phosphorylation of EGFR and MAPK, which decrease transcription of the gene MUC5AC which produces mucin.

In the case of acetaminophen overdoses, a portion of the drug is metabolized by CYP2E1 to form the potentially toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). The amount of NAPQI produced in an overdose saturates and depletes glutathione stores. The free NAPQI promiscuously binds to proteins in hepatocytes, leading to cellular necrosis. Hoestbruisten HTP Acetylcysteïne can directly conjugate NAPQI or provide cysteine for glutathione production and NAPQI conjugation.

Dosage

Hoestbruisten HTP Acetylcysteïne dosage

Hoestbruisten HTP Acetylcysteïne Tablet:

The dispersible tablet should be dissolved in 1/2 glass of water before use (preferably in the evening). The duration of treatment should be 5 to 10 days in the acute phase. It may be continued in the chronic state for up to 6 months or according to the advice of the physician.

As a mucolytic:

  • Adults: 600 mg daily as a single dose.
  • In Paracetamol overdose: Initially 140 mg/kg, followed by 70 mg/kg every 4 hours for an additional 17 doses. As an antidote, Hoestbruisten HTP Acetylcysteïne is reported to be very effective when administered within 8 hours of Paracetamol overdose, with the protective effect diminishing after this time. Initiation of treatment after a lapse of 15 hours has previously been thought to be ineffective, but recent studies suggest that beneficial results may still be obtained.

Hoestbruisten HTP Acetylcysteïne Respirator Solution:

The 20% solution may be diluted to a lesser concentration with either Sodium Chloride for injection, Sodium Chloride for inhalation, sterile water for injection, or sterile water for inhalation.

As a mucolytic:

Adult:

  • 5-10 ml of 10% or 20% solution by nebulizer every 6-8 hr PRN.

Children:

  • 1-11 months: 1-2 ml of 20% or 2-4 ml of 10% solution by nebulizer every 6-8 hr PRN.
  • 12 months-11 years: 3-5 ml of 20% or 6-10 ml of 10% solution by nebulizer every 6-8 hr PRN.
  • Below 12 years: 5-10 ml of 10/20% solution by nebulizer every 6-8 hr PRN.

Diagnostic Bronchograms: 1-2 ml of 20% or 2-4 ml of 10% solution 2-3 times by nebulization or by instillation intratracheally prior to procedure.

Nebulization tent or croupette: This form of administration requires very large volumes of the solution, occasionally as much as 300 ml during a single treatment period. If a tent or croupette must be used, the recommended dose is the volume of acetylcysteine (using 20%) that will maintain a very heavy mist in the tent or croupette for the desired period. Administration for intermittent or continuous prolonged periods, including overnight, may be desirable.

Direct Instillation: When used by direct instillation, 1-2 ml of a 20% solution may be given as often as every hour. When used for the routine nursing care of patients with tracheostomy, 1-2 ml of a 20% solution may be given every 1-4 hours by instillation into the tracheostomy.

Side Effects

Generally, Hoestbruisten HTP Acetylcysteïne is well tolerated. However, mild effects such as nausea, headache, tinnitus, urticaria, stomatitis, rhinorrhoea, chills, fever, bronchospasm may be observed. Occasional cases of nausea and dyspepsia, rare cases of urticaria may be observed.

Toxicity

Patients experiencing an overdose may present with vomiting, nausea, bronchospasm, periorbital angioedema, and hypotension. Treat patients with symptomatic and supportive measures. Hemodialysis may remove some acetylcysteine from circulation as it is somewhat protein bound.

Precaution

Hoestbruisten HTP Acetylcysteïne should be given in caution in asthma patients.

Interaction

After taking Hoestbruisten HTP Acetylcysteïne orally it increases the bioavailability of Amoxicillin, but shows no effect on Doxycycline and reduces the absorption of Cefalexin. Hoestbruisten HTP Acetylcysteïne seems to increase the effects of Nitroglycerin.

Food Interaction

No interactions found.

Hoestbruisten HTP Acetylcysteïne Disease Interaction

Major: hepatic encephalopathyModerate: asthma, fluid overload, gastric hemorrhage

Volume of Distribution

The volume of distribution of acetylcysteine is 0.47 L/kg.

Elimination Route

An 11 g dose in the form of an effervescent tablet for solution reaches a mean Cmax of 26.5 µg/mL, with a Tmax of 2 hours, and an AUC of 186 µg*h/mL.

Half Life

The mean terminal half life of acetylcysteine in adults is 5.6 hours and in pre-term neonates is 11 hours.

Clearance

Hoestbruisten HTP Acetylcysteïne has a mean clearance of 0.11 L/hr/kg.

Elimination Route

An oral dose of radiolabelled acetylcysteine is 13-38% recovered in the urine in the first 24 hours, while 3% is recovered in the feces.

Pregnancy & Breastfeeding use

Pregnancy Category B. Caution should be taken in case of pregnancy & lactation while using Hoestbruisten HTP Acetylcysteïne.

Contraindication

Known hypersensitivity to active ingredient. Also contraindicated in patients suffering from phenylketonuria and peptic ulcer.

Acute Overdose

Accidental overdose of Hoestbruisten HTP Acetylcysteïne may cause nausea, vomiting or diarrhea.

Storage Condition

Protect from light & moisture, store below 25° C. Keep all medicines out of the reach of children.

FAQ

What is Hoestbruisten HTP Acetylcysteïne?

Hoestbruisten HTP Acetylcysteïne (Acetylcysteine) also known as N-acetylcysteine (NAC), is a medication that is used to treat paracetamol (acetaminophen) overdose, and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia and bronchitis. It can be taken intravenously, by mouth, or inhaled as a mist.

What is Hoestbruisten HTP Acetylcysteïne used for?

Hoestbruisten HTP Acetylcysteïne inhalation is used along with other treatments to relieve chest congestion due to thick or abnormal mucous secretions in people with lung conditions including asthma, emphysema, bronchitis and cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction).

What are the side effects of Hoestbruisten HTP Acetylcysteïne?

Hoestbruisten HTP Acetylcysteïne is Likely safe for most adults. It can cause nausea, vomiting, and diarrhea or constipation. Rarely, it can cause rashes, fever, headache, drowsiness, low blood pressure, and liver problems.

Who should not take Hoestbruisten HTP Acetylcysteïne?

If you have asthma or bleeding problems, your doctor may tell you to avoid Hoestbruisten HTP Acetylcysteïne. You will likely be told to stop Hoestbruisten HTP Acetylcysteïne 2 weeks before any elective surgery. If you're pregnant or breastfeeding, you must check with a doctor before using Hoestbruisten HTP Acetylcysteïne supplements.

How long does Hoestbruisten HTP Acetylcysteïne take to work?

The study showed that Hoestbruisten HTP Acetylcysteïne significantly reduced the symptoms of trichotillomania compared to a placebo. 56% of subjects reported "much or very much improved" on Hoestbruisten HTP Acetylcysteïne compared to 16% on placebo (sugar pill or inert substance). Significant improvement was initially noted after 9 weeks of treatment.

When is the best time to take Hoestbruisten HTP Acetylcysteïne?

Single amino acid supplements, like Hoestbruisten HTP Acetylcysteïne, are best taken on an empty stomach. The absorption of amino acids can be affected by the foods you take them with and by other amino acids.

Is Hoestbruisten HTP Acetylcysteïne safe to take daily?

There is no recommended daily allowance for Hoestbruisten HTP Acetylcysteïne, because unlike vitamins, it's not an essential nutrient. The dosage used to prevent radio contrast dye damage is 600 mg to 1200 mg every 12 hours for 48 hours.

What are the benefits of taking Hoestbruisten HTP Acetylcysteïne?

Classic mucolytic drugs such as Hoestbruisten HTP Acetylcysteïne decrease the viscoelastic properties of mucus by reducing disulfide bonds. In contrast, expectorants change mucus consistency and make coughing more productive, mucokinetics improve transportability, and mucoregulators suppress mucus secretion.

Does Hoestbruisten HTP Acetylcysteïne really work?

Hoestbruisten HTP Acetylcysteïne supplements have been used to improve COPD symptoms, exacerbations and lung decline. In a one-year study, 600 mg of Hoestbruisten HTP Acetylcysteïne twice a day significantly improved lung function and symptoms in those with stable COPD. Those with chronic bronchitis can also benefit from Hoestbruisten HTP Acetylcysteïne.

Is Hoestbruisten HTP Acetylcysteïne safe in pregnancy?

Animal studies did not show teratogenicity; slightly decreased fertility was seen at doses above the maximum human dose. Limited case reports did not report any adverse fetal or neonatal outcomes. This drug crosses the placenta and was measurable in the serum of the infant. Pregnant women should be managed the same way as nonpregnant patients for acetaminophen overdose, and that acetylcysteine therapy was protective to both mother and fetus. There are no controlled data in human pregnancy. Use is not recommended unless clearly needed.

Is Hoestbruisten HTP Acetylcysteïne safe during Breastfeeding?

Animal studies did not show adverse effects during lactation. It is unknown in this drug or its metabolites are excreted in milk. Based on the pharmacokinetics, it should be nearly cleared 30 hours after administration. Use is not recommended.


*** Taking medicines without doctor's advice can cause long-term problems.
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