Home Plus Disinfectant

Home Plus Disinfectant Uses, Dosage, Side Effects, Food Interaction and all others data.

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (Ricinus communis L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of Ricinoleic acid, which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic, and less than 1% linolenic fatty acids . Ricinoleic acid has a hydroxyl group that provides a functional group location for various chemical reactions, making it a favourable substance in industrial applications . Castor oil does not contain ricin, which is a natural poison found in the castor oil plant; the toxic lectin remains in the bean pulp following oil isolation . Due to its renewability and high versatility in addition to being the only commercial source of a hydroxylated fatty acid , castor oil has been used as a vital raw material for the chemical industry . Castor oil was mainly used in the manufacturing of soaps, lubricants, and coatings . It is an FDA-approved food additive directly added to food products for human consumption. It can also be found in hard candies as a release agent and anti-sticking agent, or supplementary vitamins and mineral oral tablets as an ingredient for protective coatings. Castor oil is found in over-the-counter oral liquids as a stimulant laxative, and is also added in commercial cosmetic, hair, and skincare products.

Castor oil is a potent laxative that was shown to be effective for short-term constipation. In a prospective study, the group receiving oral castor oil was associated with a higher likelihood of initiation of labour compared to the placebo group . Castor oil is known to induce diarrhea, and has been used in studies to assess anti-diarrheal effect of some compounds .

Chloroxylenol is used in hospitals and households for disinfection and sanitation. It is also commonly used in antibacterial soaps, wound-cleansing applications and household antiseptics such as liquid (to which it contributes its distinctive odor), cream and ointments.

Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use . It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria .

Home Plus Disinfectant
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Home Plus Disinfectant
Generic	Aqua + Isopropyl + Alcohol + Pine Oil + castor Oil + Chloroxylenol + Koh
Weight	100mg
Type	Liquid
Therapeutic Class
Manufacturer	Pakshoo Chem & Manufacturing Co
Available Country	Iran, Nigeria
Last Updated:	September 19, 2023 at 7:00 am

Uses

Castor oil is an ingredient used in a variety of natural health products.

Indicated for over-the-counter use as a laxative for oral use and as a soothing agent for topical use on skin and hair.

Disinfectant for skin and gloved hands; obstetrics, antiseptic lubricant for vaginal examinations and on forceps; for hand antisepsis .

Home Plus Disinfectant is also used to associated treatment for these conditions: Constipation, Occasional ConstipationSkin Infections, Oral Hygiene, Skin disinfection

How Home Plus Disinfectant works

Castor oil is a mix of triglycerides consisting of mainly ricinolein, linoleic acid, oleic acid, palmitic acid, stearic acid, dihydroxystearic acid, and traces of other fatty acids . The main pharmacodynamic effects of castor oil are mediated by ricinoleic acid, a hydroxylated fatty acid released from castor oil by intestinal lipases . It was believed that ricinoleic acid acts as an anionic surfactant that reduces net absorption of fluid and electrolytes, and stimulates intestinal peristalsis . However, a recent study suggests that ricinoleic acid interacts with EP3 prostanoid receptors expressed on intestinal and uterine smooth muscles. Via activating EP3 prostanoid receptors on intestinal and uterine smooth muscle cells, ricinoleic acid promotes laxation and uterus contraction, respectively . EP3 receptor act as the major prostanoid receptor in the intestine mediating propulsive effects on gut motility, and activation of EP3 receptors has been demonstrated to evoke contraction of uterine smooth muscle .

As a phenol antiseptic, it is believed that the hydroxyl -OH groups of the chloroxylenol molecule binds to certain proteins on the cell membrane of bacteria, and disrupts the membrane so as to allow the contents of the bacterial cell to leak out . This allows chloroxylenol to enter the bacterial cell to bind further with more proteins and enzymes to disable the cell's functioning . At particularly high concentrations of chloroxylenol, the protein and nucleic acid content of targeted bacterial cells become coagulated and cease to function, leading to rapid cell death .

Dosage

Home Plus Disinfectant dosage

Wash with one table spoonful of Chloroxylenol to a tumbler of water (1 in 13) for urgent application, undiluted Chloroxylenol may be used but not in a sensitive skin.

Side Effects

Skin sensitivity; irritation of conjunctiva, mucosal irritation; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling.

Toxicity

Castor oil is considered minimally toxic when administered orally to humans; the estimated lethal oral dose is 1-2 pints of undiluted oil . Findings from a repeat-dose study in mouse report an oral LD50 value of >5000 mg/kg and NOAEL is approximately >2500 mg/kg/day in rat . Digestive tract irritation following oral ingestion, skin contact sensitization, and contact dermatitis have been reported for castor oil .

As chloroxylenol is predominantly employed as an active ingredient in various liquids or creams as cleaners, disinfectants, or antiseptics that are generally designed to be used topically, it is widely accepted that the use of such liquids - when used appropriately - is unlikely to present a sufficient volume that could be ingested to cause any medical problems . In the event of accidental eye contact, was with Luke warm water .

Chloroxylenol is known to have a low systemic toxicity, even at dosage levels many times higher that those likely to be absorbed during normal usage of the agent .

Precaution

Condition worsens or symptoms persist for more than 7 days or clear up and occur again within a few days

Interaction

There are no known drug interactions and none well documented.

Volume of Distribution

No pharmacokinetic data available.

The only data available regarding the volume of distribution of chloroxylenol is the mean Vss of 22.45 L determined after 200 mg intravenous single dose of chloroxylenol was administered to healthy mongrel dog subjects .

Elimination Route

After oral ingestion of castor oil, ricinoleic acid is released by lipases in the intestinal lumen and absorbed in the intestine . Findings from the rat study suggest that the absorption of castor oil is inversely related to the administered dose, but the absorption is virtually complete at small doses (4g) .

No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects . After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours . After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours .

For antiseptic purposes, chloroxylenol is considered to be well-absorbed when applied to the skin .

Half Life

No pharmacokinetic data available.

One study estimated the mean terminal half-life and mean residence time after a 200 mg intravenous single dose of chloroxylenol in healthy mongrel dog subjects to be 1.7 and 1.69 hours, respectively . Alternatively, some product monographs liken chloroxylenol to a similar liquid antiseptic, triclosan, whose calculated urinary excretion half-life in man is approximately 10 hours .

Clearance

No pharmacokinetic data available.

The only data available regarding the clearance of chloroxylenol is the mean clearance rate of 13.76 L/hr following a 200 mg intravenous single dose of the substance into healthy mongrel dog subjects .

Moreover, in another study, when 8 g of chloroxylenol was administered dermal on a human subject in an alcohol/glycerin vehicle, 11% was excreted in 48 hours .