Hufaxol
Hufaxol Uses, Dosage, Side Effects, Food Interaction and all others data.
Hufaxol is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Hufaxol stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Hufaxol stimulates production of phospholipids of surfactant by alveolar cells. Hufaxol has anti-inflammatory properties. In patients with COPD, it improves airway patency. Beside these, Hufaxol also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.
| Trade Name | Hufaxol |
| Generic | Ambroxol |
| Ambroxol Other Names | Ambroxol, Ambroxolum, Bisolvon metabolite vIII, Bromhexine metabolite vIII, Bromhexine-metabolite vIII |
| Weight | 15mg/5ml |
| Type | Syrup |
| Formula | C13H18Br2N2O |
| Weight | Average: 378.108 Monoisotopic: 375.978589 |
| Protein binding | Approximately 90% |
| Groups | Approved, Investigational |
| Therapeutic Class | Cough expectorants & mucolytics |
| Manufacturer | Gratia Husada Farma |
| Available Country | Indonesia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
- • Acute and chronic diseases of respiratory tracts associated with viscid mucus including acute and chronic bronchitis
- • Productive cough
- • Inflammatory diseases of Rhinopharyngeal tract (e.g. Laryngitis, Pharyngitis, Sinusitis and Rhinitis) associated with viscid mucus
- • Asthmatic bronchitis, Bronchial asthma with difficult departure of mucus
- • Bronchiectasis
- • Chronic pneumonia.
Hufaxol is also used to associated treatment for these conditions: Airway secretion clearance therapy
How Hufaxol works
Hufaxol is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Hufaxol has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.
Dosage
Hufaxol dosage
Average daily dose (preferably after meal):Pediatric Drops:
- 0-6 months: 0.5 ml 2 times a day
- 6-12 months: 1 ml 2 times a day
- 1-2 years: 1.25 ml 2 times a day
Syrup:
- 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
- 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
- 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.
Sustained release capsule:
- Adult and children over 12 years old: 1 capsule once daily
Specific application features: Hufaxol may be prescribed to patients suffering from diabetes mellitus.
Side Effects
Gastrointestinal side-effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema may occur.
Precaution
Hufaxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Interaction
Hufaxol has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Hufaxol should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Hufaxol, might not be expectorated.
Elimination Route
Rapid and almost complete.
Half Life
7-12 hours
Pregnancy & Breastfeeding use
Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Hufaxol. However, it is advised not to use during pregnancy, especially in the 1st trimester.
Lactation: Safety during lactation has not been established.
Contraindication
Contraindicated in known hypersensitivity to Hufaxol or Bromhexine.
Interaction with other Medicine
Hufaxol has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Hufaxol should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Hufaxol, might not be expectorated.
Innovators Monograph
You find simplified version here Hufaxol
Hufaxol contains Ambroxol see full prescribing information from innovator Hufaxol Monograph, Hufaxol MSDS, Hufaxol FDA label
FAQ
What is Hufaxol used for?
Hufaxol is used for conditions where there are a lot of thick mucus in the airway passages. Hufaxol belongs to a group of medications called mucolytics.It is used in the treatment of respiratory diseases associated with viscid or excessive mucus.
How safe is Hufaxol?
Hufaxol is a safe and well-tolerated treatment of bronchopulmonary diseases with a well-balanced and favorable benefit-risk profile.
How does Hufaxol work?
Hufaxol works by thinning down the mucus in the airway passages, thus making the mucus less sticky and it also facilitates the removal of the mucus from the airways.
What are the common side effects of Hufaxol?
Common side effects of Hufaxol are include:
- Nausea
- Vomiting
- Diarrhea
- Gastrointestinal side effects
- Skin rash
- itching
- Infections
- Allergies
- Upset stomach
- Dizziness
- Weakness
- Dry mouth
- Indigestion
- Numbness in throat
- Numbness in mouth
- Taste disturbances
Is Hufaxol safe during pregnancy?
Hufaxol is not advisable to taken during the first trimester of pregnancy. Please seek your doctor's or pharmacist's advice before using Hufaxol if you are pregnant.
Is Hufaxol safe during breastfeeding?
As Hufaxol is excreted in breast milk, it is not recommended to be taken while breastfeeding. Please seek your doctor's or pharmacist's advice before using this medication if you breastfeeding.
Can I drink alcohol with Hufaxol?
No. Even though you can readily find products containing dextromethorphan OTC, these medicines can be very dangerous when mixed with alcohol.
Can I drive after taking Hufaxol?
It is advisable not to drive any motor vehicle or operate heavy machinery as increased drowsiness and dizziness can occur after taking.
When should be taken of Hufaxol?
The recommended dose is 30mg to be taken three times a day.
How long does Hufaxol take to work?
When administered orally onset of action occurs after about 30 minutes.
How long should I take Hufaxol?
Hufaxol was administered intramuscularly daily for 6-10 days at the following dosages: 1.7 mg/kg (children <2 years), 1.6 mg/kg (children 2-5 years) and 1.2 mg/kg (6-10 years).
What happens if I miss a dose?
If you miss a dose, use this drug as soon as you find it. Skip the missed dose and restart your dosing schedule if it is close to the time of your next dose. Do not use an additional dose in order to make up for the missing dose.
What happens if I overdose of Hufaxol?
Do not take more than the dosage given. Your symptoms will not be changed by taking more medication; they can instead cause poisoning or severe side effects. If you believe that you or someone else might have overdosed on Hufaxol Hydrochloride Syrup, please go to the nearest hospital or nursing home emergency room.
Who should not take Hufaxol?
If you have serious gastric ulceration, liver or kidney issues, notify your healthcare professionals. If you have a confirmed history of an allergy to Hufaxol, or any of the other ingredients mentioned in the medicine, this drug should be avoided.
Can I take Hufaxol on an empty stomach?
The tablets may be taken with or without food.
Is Hufaxol for dry cough?
Hufaxol is more effective in productive cough treatment associated with the formation of sticky and thick mucus in the airway passages and is difficult to clear.Hufaxol reduces its thickness and makes its removal easier from the airways passage.
Is Hufaxol good for itchy throat?
Hufaxol has a beneficial pain-relieving effect in patients with acute sore throat, superior to that achieved by sucking a placebo lozenge.
Is Hufaxol a steroid?
No, it is not an antibiotic or steroid; it belongs to a class of medicines called Expectorants or Mucolytics. It has no known effect against infections.
How often should I take Hufaxol?
The recommended dose for adults is 1 tablet 3 times daily. For better effect, the patient may administer 2 tablets 2 times daily. The tablets should be taken with liquid.
Is Hufaxol an antibiotic?
Hufaxol is a mucolytic agent used in the treatment of respiratory diseases.
