Human Protein C

Human Protein C Uses, Dosage, Side Effects, Food Interaction and all others data.

Human Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Human Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Human Protein C (APC). Once in its activated form, APC functions as a serine protease with potent anticoagulant effects, especially in the presence of its cofactor protein S. APC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot formation.

The Human Protein C pathway provides a natural mechanism for control of the coagulation system and prevention of excessive procoagulant responses to activating stimuli. A lack of protein C in the body would lead to unchecked coagulation activation, resulting in thrombin generation and intravascular clot formation.

Human Protein C is available in concentrated form as the product Ceprotin, which is indicated for use in pediatric and adult patients with severe congenital protein C deficiency for the prevention and treatment of venous thrombosis and purpura fulminans.

Trade Name Human Protein C
Generic Protein C
Protein C Other Names autoprothrombin IIA, blood coagulation factor XIV, Human protein C, Protein C (coagulation inhibitor), Protein C concentrate, Protein C concentrate (human), Protein C concentrate human, Protein C human
Type
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Human Protein C
Human Protein C

Uses

Human Protein C is a medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis.

Human Protein C concentrate is indicated for pediatric and adult patients with severe congenital protein C deficiency for the prevention and treatment of venous thrombosis and purpura fulminans. It is also found as a component of some prothrombin complex concentrate (i.e. Factor IX Complex (Human)) formulations, such as Kcentra.

Human Protein C is also used to associated treatment for these conditions: Purpura Fulminans, Thrombosis, Venous

How Human Protein C works

Human Protein C is an endogenously occurring plasma protein that plays a key role within the coagulation cascade. Also known as blood coagulation factor XIV, Human Protein C is a zymogen, or enzyme precursor, of a vitamin K-dependent anticoagulant glycoprotein (serine protease) that is synthesized in the liver. It is converted by the thrombin/thrombomodulin-complex on the endothelial cell surface to Activated Human Protein C (APC). Once in its activated form, APC functions as a serine protease with potent anticoagulant effects, especially in the presence of its cofactor protein S. APC exerts its effect by inactivating essential components of the coagulation cascade (specifically factors V and VIII), which leads to a decrease in thrombin formation, and therefore a reduction in clot formation.

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Volume of Distribution

Volume of distribution at steady state = 0.74 dL/kg

Elimination Route

Cmax = 110 IU/dL Tmax = 0.50 hr

Half Life

Initial half life = 7.8 hr Terminal half life = 9.9 hr

Clearance

CL = 0.0533 dL/kg/h

Innovators Monograph

You find simplified version here Human Protein C

*** Taking medicines without doctor's advice can cause long-term problems.
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