Hydroxyethyl Starch

Hydroxyethyl Starch Uses, Dosage, Side Effects, Food Interaction and all others data.

Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.

After isovolemic exchange of blood with 500 mL of HES in healthy volunteers, blood volume is maintained for at least 6 hours

Trade Name Hydroxyethyl Starch
Generic Hydroxyethyl Starch
Hydroxyethyl Starch Other Names HAES, Hetastarch, Hydroxyethylstarch
Type
Protein binding

Data not found.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Hydroxyethyl Starch
Hydroxyethyl Starch

Uses

Hydroxyethyl Starch is a plasma volume substitute used to treat and prevent hypovolemia.

An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.

Hydroxyethyl Starch is also used to associated treatment for these conditions: Hypovolaemia, Granulocyte yield increase

How Hydroxyethyl Starch works

Hydroxyethyl starch (HES) is one of the most frequently used plasma substitutes. Recent studies have indicated that HES may reduce capillary leakage.

Toxicity

LDF50 (IV, rabbit): 8460 mg/Kg.

Food Interaction

No interactions found.

Volume of Distribution

5.9 L.

Elimination Route

Peak concentration (C(max), 4.34 mg/mL)

Half Life

Terminal half-life is 16.1 h. Elimination half-life is 12 h.

Clearance

31.4 mL/min

Elimination Route

Approximately 62 % of HES was excreted as hydroxyethyl starch molecules in urine within 72 hours.

Innovators Monograph

You find simplified version here Hydroxyethyl Starch

*** Taking medicines without doctor's advice can cause long-term problems.
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