Hydroxyl

Hydroxyl Uses, Dosage, Side Effects, Food Interaction and all others data.

Glycerin is a hyperosmotic laxative, given rectally, which usually produces a bowel movement within 15 minutes to 1 hour. Hyperosmotic laxatives encourage bowel movements by drawing water into the bowel from surrounding tissues. This produces a softer stool mass and increased bowel action. These products are used for fast, predictable relief of occasional constipation.

Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes.

Hydrogen peroxide is an oxidising agent with antibacterial and antiviral activity. It is used as an antiseptic, disinfectant, and deodorant. It also has a mild haemostatic action. It exerts its antiseptic action partly by its ready release of oxygen when applied to tissues, but this effect is reduced in the presence of organic matter. The mechanical effect of effervescence may be more useful for wound cleansing than the antimicrobial action.

Hydrogen peroxide exhibits antimicrobial properties against most forms of microorganisms, including dormant forms with known high resistance profiles, such as bacterial spores and protozoal cysts. It acts as an oxidative biocide to generate free radical species to induce DNA, protein and membrane lipid damage via oxidation.

Hydroxyl
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Hydroxyl
Generic	Hydrogen Peroxide + Glycerin
Weight	1.5%
Type	Mouth Wash
Therapeutic Class
Manufacturer	Opsiscare Lifesciencse Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the relief of occasional constipation

Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. This product should not be used to treat deep wounds, animal bites, or serious burns.

Hydroxyl is also used to associated treatment for these conditions: Cold Sore, Constipation, Dry Mouth, Dry Skin, Dry throat, Edema of the cerebrum, Hypertension Intracranial, Occasional Constipation, Ocular Discomfort, Ocular Hypertension, Ocular Irritation, Skin Infections, Sore Throat, Mouth soreness, Ocular burning, Bowel preparation therapy, Topical Antisepsis, Skin protectionEar infection bacterial, Seborrheic Keratosis (SK), Excess ear wax, Superficial skin infections

How Hydroxyl works

When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.

The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids in vivo . The oxidizing radical as the ferryl radical induces DNA oxidation .

Dosage

Hydroxyl dosage

Children under 2 years: Consult a physician.

Children (2 to 6 years): only 1 Glycerin 1.15 suppository per 24 hours or as directed by a physician.

Adults and Children (From 6 years): only 1 Glycerin 2.30 suppository per 24 hours or as directed by a physician

Insert suppository well up into rectum. Suppository need to melt completely to produce laxative action.

Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor orpharmacist. Donot use in theeyesor apply over large areas ofskin.

If you are using this product on the skin, clean the affected area before use. Apply a small amount of product on the affected area, usually 1 to 3 times daily or as directed by your doctor. If you apply a bandage after using this product, let the area dry first.

If you are using this product as amouthrinse, mix with an equal amount of water before using. Swish in themouthover the affected area for at least 1 minute, then spit out. Do not swallow this product. Rinse up to 4 times daily or as directed by your dentist or doctor.

Use this product regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Tell your doctor if your condition does not improve in 7 days or if it worsens. If you think you may have a serious medical problem, seek immediate medical attention.

Side Effects

Glycerin when used rectally may cause rectal discomfort or a burning sensation

Irritating burns on the skin and mucous membranes (strong solutions); reversible hypertrophy of the papillae of the tongue with continued use as mouthwash; gas embolism, rupture of the colon, proctitis, ulcerative colitis and gangrene of the intestines have occurred following colonic lavage with hydrogen peroxide solution.

Toxicity

Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg

Oral LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig. LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours .

Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans. Inhalation of highly concentrated vapours causes extreme irritation of nose and throat .

Hydrogen peroxide has no known carcinogenic potential. It was shown to be mutagenic to bacteria (Salmonella typhimurium) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli . It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro .

Precaution

Before using hydrogen peroxide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Interaction

If you are using this product under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Volume of Distribution

Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.

Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney .

Elimination Route

Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach

It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue .

Half Life

30 - 45 minutes

Elimination Route

Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.

Pregnancy & Breastfeeding use

Pregnancy category C. There are no controlled data in human pregnancy

Hydrogen peroxide is safe to use during pregnancy. It is unlikely that this product passes into breast milk. Consult your doctor before breast-feeding.