Hypoten (Clopamide_Dihydroergocristine mesilate_Reserpine)

Hypoten (Clopamide_Dihydroergocristine mesilate_Reserpine) Uses, Dosage, Side Effects, Food Interaction and all others data.

Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure.

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.

Table Of contents

• Hypoten (Clopamide_Dihydroergocristine mesilate_Reserpine)
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Hypoten (Clopamide_Dihydroergocristine mesilate_Reserpine)
Generic	Clopamide + Dihydroergocristine Mesilate + Reserpine
Type
Therapeutic Class
Manufacturer
Available Country	Egypt
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of hypertension

Hypoten (Clopamide_Dihydroergocristine mesilate_Reserpine) is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)High Blood Pressure (Hypertension), Agitated psychotic state

How Hypoten (Clopamide_Dihydroergocristine mesilate_Reserpine) works

Reserpine's mechanism of action is through inhibition of the ATP/Mg²⁺ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.

Toxicity

Possible human carcinogen. May cause reproductive harm. ORL-RAT LD₅₀ 420 mg/kg; IPR-RAT LD₅₀ 44 mg/kg; IVN-RAT LD₅₀ 15 mg/kg; ORL-MUS LD₅₀ 200 mg/kg; SCU-MUS LD₅₀ 52 mg/kg; IPR-RBT LD₅₀ 7 mg/kg

Elimination Route

Reserpine is extensively metabolized to inactive compounds. It is slowly excreted via the urine and feces.

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