Hystol Antiseptic Disinfectant

Uses

Disinfectant for skin and gloved hands; obstetrics, antiseptic lubricant for vaginal examinations and on forceps; for hand antisepsis .

For the disinfection of clean and intact skin. For pre-operative surgical hand disinfection, hand disinfection on the ward prior to aseptic procedures or after handling contaminated materials. For disinfection of the patients' skin prior to surgery or other invasive procedures

Hystol Antiseptic Disinfectant is also used to associated treatment for these conditions: Skin Infections, Oral Hygiene, Skin disinfectionInfection, Preoperative Skin Preparation, Skin disinfection, Prophylaxis of bacterial skin infections

How Hystol Antiseptic Disinfectant works

As a phenol antiseptic, it is believed that the hydroxyl -OH groups of the chloroxylenol molecule binds to certain proteins on the cell membrane of bacteria, and disrupts the membrane so as to allow the contents of the bacterial cell to leak out . This allows chloroxylenol to enter the bacterial cell to bind further with more proteins and enzymes to disable the cell's functioning . At particularly high concentrations of chloroxylenol, the protein and nucleic acid content of targeted bacterial cells become coagulated and cease to function, leading to rapid cell death .

Dosage

Hystol Antiseptic Disinfectant dosage

Wash with one table spoonful of Chloroxylenol to a tumbler of water (1 in 13) for urgent application, undiluted Chloroxylenol may be used but not in a sensitive skin.

Squeeze thumbnail size amount in your palm then briskly rub hands together until dry. Use as often as required.

To completely remove germs from hands wash your hand with this Anti-Germ Hand Wash for 20 seconds using the below WHO recommended 7 steps:

• Step 1: Wet Hands. Wet your hands and apply enough liquid soap to create a good lather.
• Step 2: Rub Palms Together.
• Step 3: Rub the Back of Hands.
• Step 4: Interlink Your Fingers.
• Step 5: Cup Your Fingers.
• Step 6: Clean the Thumbs.
• Step 7: Rub Palms with Your Fingers.

Side Effects

Skin sensitivity; irritation of conjunctiva, mucosal irritation; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling.

Toxicity

As chloroxylenol is predominantly employed as an active ingredient in various liquids or creams as cleaners, disinfectants, or antiseptics that are generally designed to be used topically, it is widely accepted that the use of such liquids - when used appropriately - is unlikely to present a sufficient volume that could be ingested to cause any medical problems . In the event of accidental eye contact, was with Luke warm water .

Chloroxylenol is known to have a low systemic toxicity, even at dosage levels many times higher that those likely to be absorbed during normal usage of the agent .

Precaution

Condition worsens or symptoms persist for more than 7 days or clear up and occur again within a few days

• Highly Flammable. Keep away from fire or flame
• For external use only
• Avoid eyes. In case of contact with eye, flush with water
• Discontinue use if skin irritation occurs
• Keep out of reach of children

Interaction

There are no known drug interactions and none well documented.

Volume of Distribution

The only data available regarding the volume of distribution of chloroxylenol is the mean Vss of 22.45 L determined after 200 mg intravenous single dose of chloroxylenol was administered to healthy mongrel dog subjects .

Elimination Route

No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects . After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours . After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours .

For antiseptic purposes, chloroxylenol is considered to be well-absorbed when applied to the skin .

Half Life

One study estimated the mean terminal half-life and mean residence time after a 200 mg intravenous single dose of chloroxylenol in healthy mongrel dog subjects to be 1.7 and 1.69 hours, respectively . Alternatively, some product monographs liken chloroxylenol to a similar liquid antiseptic, triclosan, whose calculated urinary excretion half-life in man is approximately 10 hours .

Clearance

The only data available regarding the clearance of chloroxylenol is the mean clearance rate of 13.76 L/hr following a 200 mg intravenous single dose of the substance into healthy mongrel dog subjects .

Moreover, in another study, when 8 g of chloroxylenol was administered dermal on a human subject in an alcohol/glycerin vehicle, 11% was excreted in 48 hours .

Elimination Route

The major route of excretion is likely in urine , although some amounts may be found in bile and traces in exhaled air .

Pregnancy & Breastfeeding use

Pregnancy Category-Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

Contraindication

Hypersensitivity

Storage Condition

Isopropyl alcohol should be stored in a tightly closed container in a cool & dry place, protected from light, well-ventilated area. Due to the chemical's extreme flammability, it must be kept away from all possible ignition sources, including heat, sparks, and flames. Keep out of reach of children.

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