I Box
I Box Uses, Dosage, Side Effects, Food Interaction and all others data.
I Box is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. I Box has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.
I Box is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. I Box is an a-ariloxybenzyl derivative of morpholine. I Box is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders.
| Trade Name | I Box |
| Generic | Reboxetine |
| Reboxetine Other Names | Reboxetina, Reboxetine |
| Type | Tablet |
| Formula | C19H23NO3 |
| Weight | Average: 313.397 Monoisotopic: 313.167793605 |
| Protein binding | 98% |
| Groups | Approved, Experimental |
| Therapeutic Class | |
| Manufacturer | Rkg Pharma Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
I Box is a drug used for the acute treatment of major depression and for maintenance therapy of depression.
For the treatment of clinical depression.
I Box is also used to associated treatment for these conditions: Major Depressive Disorder (MDD), Maintenance
How I Box works
I Box is a selective inhibitor of noradrenaline reuptake. It inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine. I Box does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.
Toxicity
Reports of seizures (rare) have been reported
Elimination Route
I Box is rapidly and extensively absorbed following oral administration.
Half Life
12.5 hours
Innovators Monograph
You find simplified version here I Box
