Icodextrine

Icodextrine Uses, Dosage, Side Effects, Food Interaction and all others data.

Icodextrine is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.

Table Of contents

• Icodextrine
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Icodextrine
Generic	Icodextrin
Icodextrin Other Names	Icodextrin, Icodextrina, Icodextrine, Icodextrinum
Type
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Icodextrine is an iso-osmotic solution used for continuous peritoneal dialysis or automated peritoneal dialysis.

Used for continuous ambulatory peritoneal dialysis (CAPD) of diabetic patients or automated peritoneal dialysis (APD) for the management of end-stage renal disease.

Icodextrine is also used to associated treatment for these conditions: Dialysis therapy

How Icodextrine works

Icodextrine is a starch-derived, water-soluble glucose polymer linked by alpha (1-4) and alpha (1-6) glycosidic bonds with an average molecular weight between 13,000 and 19,000 daltons. It functions as a colloid osmotic agent to achieve ultrafiltration during long (12-16 hour) peritoneal dialysis dwells. In other words it helps clean waste out of the body when the kidneys are not functioning properly. Icodectrin acts in the peritoneal cavity by exerting osmotic pressure across small intercellular pores resulting in transcapillary ultrafiltration through the dwell. This is due to the fact that the polymer is minimially absorbed across the peritoneal membrane. Icodextrine achieves superior fluid removal compared with glucose-based dialysates.

Food Interaction

No interactions found.

Elimination Route

40% of instilled icodextrin was absorbed from the peritoneal solution during a 12-hour dwell.

Innovators Monograph

You find simplified version here Icodextrine