IFN-gamma 1b
IFN-gamma 1b Uses, Dosage, Side Effects, Food Interaction and all others data.
Human IFN-gamma 1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography.The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, IFN-gamma 1b may prevent excessive scarring.
| Trade Name | IFN-gamma 1b |
| Generic | Interferon gamma-1b |
| Interferon gamma-1b Other Names | IFN-gamma 1b, IFN-gamma-1b, Interferon gamma 1-b, Interferon gamma-1b, Interferon gamma-1b, recombinant, Interferon gamma-2a |
| Type | |
| Formula | C761H1206N214O225S6 |
| Weight | 17145.6 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
IFN-gamma 1b is a form of recombinant human interferon used to treat infections associated with chronic granulomatous disease and to slow the progression of severe malignant osteopetrosis.
IFN-gamma 1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
IFN-gamma 1b is also used to associated treatment for these conditions: Chronic Granulomatous Disease (CGD), Severe, malignant Osteopetrosis
How IFN-gamma 1b works
Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
Food Interaction
- Avoid excessive or chronic alcohol consumption. IFN-gamma 1b may cause fatigue, drowsiness, and confusion. These effects may be exacerbated by alcohol consumption.
Innovators Monograph
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