Ilaris (Subcutaneous)

Ilaris (Subcutaneous) Uses, Dosage, Side Effects, Food Interaction and all others data.

Ilaris (Subcutaneous) is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. Both heavy chains of canakinumab contain oligosaccharide chains linked to the protein backbone at asparagine 298 (Asn 298). Ilaris (Subcutaneous) binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1alpha or IL-1 receptor antagonist (IL-1ra). Ilaris (Subcutaneous) is marketed under the brand name Ilaris and indicated for patients 4 years of age and older to treat Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), which are both part of the Cryopyrin-Associated Periodic Syndromes (CAPS) as well as for patients 2 years of age and older to treat systemic juvenile idiopathic arthritis (SJIA). Clinical trials have established the administration of canakinumab every 2 weeks to be safe and effective, offering a considerable advantage over the existing treatment with the human IL-1 receptor antagonist, anakinra, which must be injected daily and which is often poorly tolerated by patients.

Novartis AG has developed canakinumab as a subcutaneous injection and fully human mAb that neutralizes the bioactivity of human IL-1beta, which is involved in several inflammatory disorders. Ilaris (Subcutaneous) has promising clinical safety and pharmacokinetic properties, and demonstrated potential for the treatment of cryopyrin-associated periodic syndromes (CAPS), systemic juvenile idiopathic arthritis (SJIA), and possibly for other complex inflammatory diseases, such as rheumatoid arthritis, COPD disease and ocular diseases.

Trade Name Ilaris (Subcutaneous)
Availability Prescription only
Generic Canakinumab
Canakinumab Other Names Canakinumab
Related Drugs Actemra, Kineret, Ilaris, Humira, methotrexate, colchicine, Enbrel, Xeljanz, adalimumab, Orencia
Type
Formula C6452H9958N1722O2010S42
Weight 145200.0 Da
Protein binding

Canakinumab binds to plasma IL-1β, but plasma protein binding was not quantified.

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country USA
Last Updated: September 19, 2023 at 7:00 am
Ilaris (Subcutaneous)
Ilaris (Subcutaneous)

Uses

Ilaris (Subcutaneous) is an interleukin-1β blocker used to treat Periodic Fever Syndromes such as Cryopyrin-Associated Periodic Syndromes (CAPS) and Familial Mediterranean Fever (FMF), and also to treat active Systemic Juvenile Idiopathic Arthritis (SJIA).

Used in patients 4 years of age and older to treat Familial Cold Autoinflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS), which are both part of the Cryopyrin-Associated Periodic Syndromes (CAPS) as well as for patients 2 years of age and older to treat systemic juvenile idiopathic arthritis (SJIA).

Ilaris (Subcutaneous) is also used to associated treatment for these conditions: Familial Cold Autoinflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), Neonatal-Onset Multisystem Inflammatory Disease (NOMID), Active systemic Juvenile idiopathic arthritis

How Ilaris (Subcutaneous) works

In inflammatory diseases involving Cryopyrin-Associated Periodic Syndromes (CAPS), interleukin-1 beta (IL-1β) is excessively activated and drives inflammation. The protein cryopyrin controls the activation of IL-1β, and mutations in cryopyrin's gene, NLRP-3, up-regulate IL-1β activation. Ilaris (Subcutaneous) is a human monoclonal anti-human IL-1β antibody of the IgG1/κ isotype. Ilaris (Subcutaneous) binds to human IL-1β and neutralizes its inflammatory activity by blocking its interaction with IL-1 receptors, but it does not bind IL-1α or IL-1 receptor antagonist (IL-1ra).

Toxicity

The most common adverse reactions involved the central nervous system (headache and vertigo), gastrointestinal system (diarrhea and nausea), neuromuscular and skeletal system (musculoskeletal pain), and respiratory system (rhinitis, nasopharyngitis and bronchitis). Influenza was also reported.

Food Interaction

  • Take with or without food.

Ilaris (Subcutaneous) Disease Interaction

Major: immunizationModerate: infections, tuberculosis

Volume of Distribution

  • 6.01 L [typical CAPS patient weighing 70 kg]

Elimination Route

The absolute bioavailability of subcutaneous canakinumab is estimated to be 70%.

Half Life

26 days

Clearance

  • 0.174 L/day [typical CAPS patient weighing 70 kg]

Elimination Route

The route of elimination for canakinumab has not yet been determined.

Innovators Monograph

You find simplified version here Ilaris (Subcutaneous)

*** Taking medicines without doctor's advice can cause long-term problems.
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