Iloprost

Iloprost Uses, Dosage, Side Effects, Food Interaction and all others data.

Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).

Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.

Iloprost
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Iloprost
Availability	Prescription only
Generic	Iloprost
Iloprost Other Names	Iloprost
Related Drugs	sildenafil, tadalafil, Revatio, Adempas, Opsumit, ambrisentan
Type	Solution
Formula	C₂₂H₃₂O₄
Weight	Average: 360.494 Monoisotopic: 360.23005951
Protein binding	60%
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Zentiva
Available Country	United Kingdom, United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Iloprost is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).

Used for the treatment of pulmonary arterial hypertension.

Iloprost is also used to associated treatment for these conditions: NYHA class III Pulmonary arterial hypertension, NYHA class IV Pulmonary arterial hypertension

How Iloprost works

Iloprost is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. Iloprost binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. Iloprost constricts the ilium and fundus circular smooth muscle as strongly as prostaglandin E2 (PGE2) itself. Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. All of these properties help to antagonize the pathological changes that take place in the small pulmonary arteries of patients with pulmonary hypertension.

Toxicity

Overdoses can lead to hypotension, headache, flushing, nausea, vomiting, and diarrhea.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking iloprost with anticoagulant/antiplatelet herbs may increase the risk of bleeding occurring as an adverse effect. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.