Increvil

Increvil Uses, Dosage, Side Effects, Food Interaction and all others data.

Increvil is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, Increvil increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner.

Increvil works to improve glycemic control in type II diabetes mellitus by enhancing the glucose sensitivity of beta-cells (β-cells) in pancreatic islets and promoting glucose-dependent insulin secretion. Increased GLP-1 levels leads to enhanced sensitivity of alpha cells to glucose, promoting glucagon secretion. Increvil causes an increase in the insulin to glucagon ratio by increasing incretin hormone levels: this results in a decrease in fasting and postprandial hepatic glucose production. Increvil does not affect gastric emptying. It also has no effects on insulin secretion or blood glucose levels in individuals with normal glycemic control.

In clinical trials, treatment with vildagliptin 50-100 mg daily in patients with type 2 diabetes significantly improved markers of beta-cells, proinsulin to insulin ratio, and measures of beta-cell responsiveness from the frequently-sampled meal tolerance test. Increvil has improves glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) levels.

Trade Name Increvil
Generic Vildagliptin
Vildagliptin Other Names Vildagliptin, Vildagliptina
Type Tablet
Formula C17H25N3O2
Weight Average: 303.3993
Monoisotopic: 303.194677059
Protein binding

The plasma protein binding of vildagliptin is 9.3%. Vildagliptin distributes equally between plasma and red blood cells.

Groups Approved, Investigational
Therapeutic Class Dipeptidyl Peptidase-4 (DPP-4) inhibitor
Manufacturer Saan Labs
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Increvil
Increvil

Uses

Increvil is used for an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

  • As monotherapy
  • In dual combination with Metformin, a Sulphonylurea, a Thiazolidinedione, or Insulin when diet, exercise and a single antidiabetic agent do not result in adequate glycemic control.

Increvil is also used to associated treatment for these conditions: Type 2 Diabetes Mellitus

How Increvil works

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones that regulate blood glucose levels and maintain glucose homeostasis. It is estimated that the activity of GLP-1 and GIP contribute more than 70% to the insulin response to an oral glucose challenge. They stimulate insulin secretion in a glucose-dependent manner via G-protein-coupled GIP and GLP-1 receptor signalling. In addition to their effects on insulin secretion, GLP-1 is also involved in promoting islet neogenesis and differentiation, as well as attenuating pancreatic beta-cell apoptosis. Incretin hormones also exert extra-pancreatic effects, such as lipogenesis and myocardial function. In type II diabetes mellitus, GLP-1 secretion is impaired, and the insulinotropic effect of GIP is significantly diminished.

Increvil exerts its blood glucose-lowering effects by selectively inhibiting dipeptidyl peptidase-4 (DPP-4), an enzyme that rapidly truncates and inactivates GLP-1 and GIP upon their release from the intestinal cells. DPP-4 cleaves oligopeptides after the second amino acid from the N-terminal end. Inhibition of DPP-4 substantially prolongs the half-life of GLP-1 and GIP, increasing the levels of active circulating incretin hormones. The duration of DPP-4 inhibition by vildagliptin is dose-dependent. Increvil reduces fasting and prandial glucose and HbA1c. It enhances the glucose sensitivity of alpha- and beta-cells and augments glucose-dependent insulin secretion. Fasting and postprandial glucose levels are decreased, and postprandial lipid and lipoprotein metabolism are also improved.

Dosage

Increvil dosage

The recommended dose of Increvil is-

  • 50 mg or 100 mg daily for monotherapy.
  • 50 mg twice daily (morning and evening) when used in dual combination with Metformin or a Thiazolidinedione;
  • 50 mg once daily in the morning when used in dual combination with a Sulphonylurea.

Increvil may be taken with or without a meal. No dosage adjustment is required in the elderly, or in patients with mild renal impairment.

Side Effects

The majority of adverse reactions were mild and transient, not requiring treatment discontinuations. Rare case of hepatic dysfunction is seen. Clinical trials of up to and more than 2 years’ duration did not show any additional safety signals or unforeseen risks when use this drug.

Toxicity

The oral Lowest published toxic dose (TDLO) is 0.3 mg/kg in rats and 1 mg/kg in mice.

There is limited information regarding overdose with vildagliptin. In one study, patients experienced muscle pain, mild and transient paresthesia, fever, edema, and a transient increase in lipase levels at a dose of 400 mg. At 600 mg, one subject experienced edema of the feet and hands and increases in creatine phosphokinase (CPK), aspartate aminotransferase (AST), C-reactive protein (CRP) and myoglobin levels. Supportive management is recommended in case of an overdose. There is no known antidote, and vildagliptin and its major metabolite cannot be removed via hemodialysis.

Precaution

Caution should be exercised in patients aged 75 years and older due to limited clinical experience. It is recommended that Liver Function Tests (LFTs) are monitored prior to initiation of Increvil, at three monthly intervals in the first year and periodically thereafter. If transaminase levels are increased, patients should be monitored with a second liver function evaluation to confirm the finding and be followed thereafter with frequent liver function tests until the abnormality (ies) return(s) to normal. If AST or ALT persist at 3 x ULN, Increvil treatment should be stopped. Patients who develop jaundice or other signs of liver dysfunction should discontinue Increvil. Following withdrawal of treatment with Increvil and LFT normalization, treatment with Increvil should not be reinitiated. Due to limited clinical experience, use with caution in patients with congestive heart failure of New York Heart Association (NYHA) functional class I–II, and do not use in patients with NYHA functional class III-IV. Increvil is not recommended in patients with moderate to severe renal impairment.

Interaction

In pharmacokinetic studies, no interactions were seen with pioglitazone, metformin, glibenclamide, digoxin, warfarin, amlodipine, ramipril, valsartan or simvastatin. As with other oral antidiabetic medicinal products the glucose-lowering effect of Increvil may be reduced by certain active substances, including thiazides, corticosteroids, thyroid products and sympathomimetics.

Food Interaction

  • Take with or without food. Food reduces Cmax and delays Tmax, but not in a clinically significant way.

Volume of Distribution

The mean volume of distribution of vildagliptin at steady-state after intravenous administration is 71 L, suggesting extravascular distribution.

Elimination Route

In a fasting state, vildagliptin is rapidly absorbed following oral administration. Peak plasma concentrations are observed at 1.7 hours following administration. Plasma concentrations of vildagliptin increase in an approximately dose-proportional manner.

Food delays Tmax to 2.5 hours and decreases Cmax by 19%, but has no effects on the overall exposure to the drug (AUC). Absolute bioavailability of vildagliptin is 85%.

Half Life

The mean elimination half-life following intravenous administration is approximately two hours. The elimination half-life after oral administration is approximately three hours.

Clearance

After intravenous administration to healthy subjects, the total plasma and renal clearance of vildagliptin were 41 and 13 L/h, respectively.

Elimination Route

Increvil is eliminated via metabolism. Following oral administration, approximately 85% of the radiolabelled vildagliptin dose was excreted in urine and about 15% of the dose was recovered in feces. Of the recovered dose in urine, about 23% accounted for the unchanged parent compound.

Pregnancy & Breastfeeding use

Pregnancy: There are no adequate data on the use of Increvil in pregnant women; hence the potential risk for human is unknown.Lactation: It is not known whether Increvil is excreted in human milk. Due to lack of human data, Increvil should not be used during lactation.

Contraindication

Increvil is contraindicated in patients with:

  • Hypersensitivity to the active substance or to any of the excipients
  • Patients with type 1 diabetes or for the treatment of diabetic ketoacidosis

Special Warning

Paediatric use: Increvil is not recommended in patients 18 years of age

Storage Condition

Store in a cool and dry place. Protect from light and moisture. Keep out of the reach of the children.

Innovators Monograph

You find simplified version here Increvil

Increvil contains Vildagliptin see full prescribing information from innovator Increvil Monograph, Increvil MSDS, Increvil FDA label

FAQ

What are the uses of Increvil?

Increvil is used for the treatment of Type 2 diabetes mellitus. This is used along with diet and exercise to improve blood sugar control in adults with Type 2 diabetes.

What are the common side effects of Increvil?

Some of the common and major side effects of Increvil are:

  • Headache
  • Cough
  • Constipation
  • Sweating
  • Hypoglycaemia
  • Weakness
  • Excessive sweating
  • Heartburn
  • Swelling of face, lips and eyelids

When should I take Increvil?

You can take the Increvil tablets before, during or after meals.If you have been told to take two doses each day, take your first dose in the morning and the second dose in the evening.

How does Increvil work in the body?

It works by blocking the breakdown of incretin hormones in the body. These hormones are released after a meal and stimulate the pancreas to produce insulin.

Is Increvil safe during pregnancy?

You should not take this Increvil during pregnancy. There are no adequate data from the use of Increvil in pregnant women. Due to lack of human data, you should not be used during pregnancy.

Is Increvil safe during breastfeeding?

You should not use Increvil if you are breast-feeding or plan to breast-feed. A safety Score of indicates that usage of Increvil may cause some minor side effects in breastfed baby.Study of different scientific research indicates that Increvil may cause moderate to no side effects in lactating mother.

Can I drink alcohol with Increvil?

Taking Increvil with alcohol may affect the control of your blood glucose.

Can I drive after taking Increvil?

If you feel dizzy while taking this medicine, do not drive or use machines.

How do you take Increvil?

You can take  Increvil any time of day ,just try to take it at the same time every day.The usual dose is 1 tablet taken once a day.Increvil can be taken with or without food. Swallow the tablets whole with a glass of water.

How safe is Increvil?

Increvil is a safe therapeutic option for patients with T2DM, both as monotherapy and as add-on treatment.Increvil is approved for use as monotherapy and in combination with other anti-hyperglycaemic agents.

Is Increvil good for diabetes?

Increvil is an important and well-tolerated treatment choice for elderly patients with type 2 diabetes, showing comparable glycemic regulation to metformin but having better GI tolerability.

Is Increvil safe for long term?

Increvil as add-on to insulin treatment for 24 months was well tolerated and led to sustained reductions in HbA1c, the dose and frequency of insulin injections, and the risk of hypoglycemia in patients with T2DM.

Does Increvil cause weight loss?

Increvil may cause modest weight loss has been observed in patients with relatively low baseline glycemia.

Is Increvil safe for kidneys?

Increvil can be safely used in T2DM patients with varying degrees of renal impairment.Dose adjustments for renal impairment are required.

What class of drug is Increvil?

Increvil is a member of a class of oral antidiabetic agents known as dipeptidyl peptidase IV inhibitors (DPP-IV) inhibitors or 'incretin enhancers'.

Can I stop taking Increvil?

Do not stop taking Increvil suddenly; speak to your doctor or nurse before stopping.

Does Increvil cause hypoglycemia?

Increvil treatment has consistently been associated with a low incidence of hypoglycemia in all clinical settings, including more vulnerable populations at higher risk for hypoglycemia, such as elderly patients or patients treated with insulin.

*** Taking medicines without doctor's advice can cause long-term problems.
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