Indecainidum

Indecainidum Uses, Dosage, Side Effects, Food Interaction and all others data.

Indecainidum is a rarely used antidysrhythmic. Indecainidum has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.

Trade Name Indecainidum
Generic Indecainide
Indecainide Other Names Indecainida, Indecainide, Indecainidum
Type
Formula C20H24N2O
Weight Average: 308.4174
Monoisotopic: 308.1888634
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Indecainidum
Indecainidum

Uses

For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.

How Indecainidum works

Indecainidum acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

Toxicity

When given orally to either young adult rats or mice, the LD50 was 100 mg/kg. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.

Elimination Route

Nearly complete following oral administration.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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