Indeparin

Indeparin Uses, Dosage, Side Effects, Food Interaction and all others data.

Indeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Indeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight of 5500 to 6500. Normiflo was withdrawn from the US market in March 2000.

Indeparin, an anticoagulant, is a fractionated heparin. It acts at multiple sites in the normal coagulation system to inhibit reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo.

Trade Name Indeparin
Availability Discontinued
Generic Ardeparin
Type A A Pf Syringe
Groups Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer Gland Pharma Limited
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Indeparin
Indeparin

Uses

For prevention of deep vein thrombosis, which may result in pulmonary embolism, following knee surgery.

How Indeparin works

Indeparin binds to antithrombin III, accelerating its activity in inactivating factor Xa and thrombin, thereby inhibiting thrombosis. Indeparin also binds to heparin cofactor II, inhibiting thrombin. Indeparin does not effect prothrombin time (PT) assays and may prolong activated partial thromboplastin time (APTT). Indeparin has double the anti-factor Xa activity versus anti-factor IIa activity, compared to unfractionated heparin which has approximately equal anti-factor Xa activity and anti-factor IIa activity.

Toxicity

Symptoms of overdose may include excessive bleeding and bruising.

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include ginseng, ginkgo, ginger, and garlic.

Indeparin Hypertension interaction

[Major] Heparin should be used with extreme caution in patients with uncontrolled or severe hypertension as these conditions may predispose the patient to hemorrhage during heparin administration.

Blood coagulation tests (e.g., whole blood clotting time, activated partial thromboplastin time) should be performed at appropriate intervals during full-dose heparin administration.

In addition, periodic platelet counts, hematocrits, and tests for occult blood in stool are recommended during the entire course of heparin therapy.

Clinical monitoring of blood pressure is recommended.

Hypertension interaction

[Moderate] Anticoagulants should be used with extreme caution in patients at increased risk for hemorrhage, including those patients with severe hypertension.

Elimination Route

Well absorbed following subcutaneous administration, with a mean bioavailability of 92% (based on anti-factor Xa activity).

Half Life

Elimination half-life for anti-factor Xa activity averages 3.3 hours following a single intravenous dose, while elimination half-life for anti-factor IIa activity averages 1.2 hours following a single intravenous dose.

Innovators Monograph

You find simplified version here Indeparin

*** Taking medicines without doctor's advice can cause long-term problems.
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