Indigo Carmine Acid
Indigo Carmine Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
Indolesulfonic acid is a blue-colored dye used a marker in urological procedures, also known as indigo carmine .
Indigo carmine, or 5, 5'-indigodisulfonic acid sodium salt, also known as indigotine or _FD& C Blue #2 _is a pH indicator with the chemical formula C16H8N2Na2O8S2. It is approved for use as a food dye in the United States and the EU and has the E number E132
This drug dyes tissues blue, enabling easier visualization for accuracy during medical procedures .
| Trade Name | Indigo Carmine Acid |
| Generic | Indigotindisulfonic acid |
| Indigotindisulfonic acid Other Names | Blue X, Indigo carmine acid, indigo carmine free acid, Indigotindisulfonate, Saxon blue |
| Type | |
| Formula | C16H10N2O8S2 |
| Weight | Average: 422.389 Monoisotopic: 421.987856686 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indigo Carmine Acid is a medication used to visualize ureteral orifices during cystoscopy and ureteral catheterization.
This drug was initially used as a kidney function test. The main application of indigo carmine at this time is localizing and visualizing ureteral orifices during cystoscopy and ureteral catheterization procedures .
How Indigo Carmine Acid works
Indigo carmine works as a dye that accumulates in crevices, cysts, and foveolae and stains the tissue blue .
According to one study, the primary action of indigo carmine appears to be at the level of nitric oxide generation and/or its release from the endothelium. In addition to this, indigo carmine appears to inhibit vascular smooth muscle guanylyl cyclase. Therefore, indigo carmine may increase blood pressure by interfering with these nitric oxide-mediated vasodilatory mechanisms .
Toxicity
After intravenous administration, the LD80 was measured at 300 mg/kg in the mouse .
Nausea, vomiting, hypertension, bradycardia and infrequently, rash, pruritus, and bronchoconstriction. Skin discoloration may occur at high doses. Anaphylaxis is a serious adverse event that has been occasionally reported .
Animal studies have not been conducted with indigotindisulfonate. It is also unknown whether indigotindisulfonate sodium injection poses a risk of fetal harm when administered to a pregnant woman or whether it may affect reproduction. Indigotindisulfonate sodium injection should be given to a pregnant woman only if absolutely necessary .
It is not known whether this drug is excreted in human breastmilk .
Food Interaction
No interactions found.Elimination Route
Biologically inert .
Half Life
4-5 minutes post-injection
Elimination Route
Indigo carmine is excreted largely by the kidneys, retaining its blue color during passage through the body.
Elimination of this dye begins rapidly after injection, appearing in the urine within 10 minutes in most cases. Larger quantities are necessary when intramuscular injection route is employed. Appearance time and elimination are delayed if given by the route of intramuscular injection .
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