Indium In 111 Pentetate
Indium In 111 Pentetate Uses, Dosage, Side Effects, Food Interaction and all others data.
Indium In 111 Pentetate disodium is a radioactive diagnostic indicated for use in radionuclide cisternography. Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column.
| Trade Name | Indium In 111 Pentetate |
| Generic | Indium In-111 pentetate |
| Indium In-111 pentetate Other Names | Indium In 111 pentetate, Indium In-111 pentetate |
| Type | |
| Formula | C14H20InN3O10 |
| Weight | Average: 501.23 Monoisotopic: 501.019979533 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indium In 111 Pentetate is a radiopharmaceutical diagnostic agent used for radionuclide cisternography.
Pentetate Indium Disodium In 111 is recommended for use in radionuclide cisternography.
How Indium In 111 Pentetate works
Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column.
Toxicity
Pregnancy Category C
Aseptic meningitis and pyrogenic reactions have been rarely (less than 0.4%) observed following cisternography
Food Interaction
No interactions found.Elimination Route
After intrathecal administration, the radiopharmaceutical is absorbed from the subarachnoid space as described below, and the remainder flows superiorly to the basal cisterns within 2 to 4 hours and subsequently will be apparent in the Sylvian cisterns, the interhemispheric cisterns, and over the cerebral convexities. In normal individuals, the radiopharmaceutical will have ascended to the parasagittal region within 24 hours with simultaneous partial or complete clearance of activity from the basal cisterns and Sylvian regions. In contrast to air, the radiopharmaceutical does not normally enter the cerebral ventricles. Although the primary absorption of cerebrospinal fluid (CSF) into the blood stream occurs at the arachnoid villi, there is some evidence that a significant fraction of CSF is also absorbed across both the cerebral and spinal leptomeninges. Lesser quantities may also be absorbed across the ventricular ependyma. It is also generally held that these alternate routes of CSF absorption may assume primary importance when the major routes of the flow are pathologically obstructed
Half Life
Indium 111 decays by electron capture with a physical half-life of 67.9 hours.
Elimination Route
Approximately 65% of the administered dose is excreted by the kidneys within 24 hours and this increases to 85% in 72 hours.
Innovators Monograph
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