Indomethacin (Oral)

Indomethacin (Oral) Uses, Dosage, Side Effects, Food Interaction and all others data.

Table Of contents

• Indomethacin (Oral)
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Indomethacin (Oral)
Generic	Indomethacin (Oral)
Type
Therapeutic Class	Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Manufacturer
Available Country	Bangladesh
Last Updated:	September 24, 2024 at 5:38 am

Uses

Indomethacin is indicated in- Rheumatoid arthritis Ankylosing spondylitis Osteoarthritis (degenerative joint disease) Gout Acute non-articular rheumatism (bursitis, synovitis, tendinitis).

Dosage

Indomethacin (Oral) dosage

75 mg sustained-release capsule: Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis (degenerative joint disease): The initial dose is 75 mg sustained-release capsule once daily. If severe then twice daily is required. Acute attacks of gout: May control with a dose of 75 mg sustained-release capsule twice daily. Acute non-articular rheumatism (bursitis, synovitis, tendinitis): 1-2 sustained-release capsule daily according to the severity of this case. 25 mg capsule: Rheumatic diseases: 50-200 mg daily in divided doses Acute gout: 150-200 mg daily in divided doses Dysmenorrhea: up to 75 mg daily

Side Effects

Headaches, usually in the morning and kild vertigo may occur during the early weeks of therapy. These symptoms are transient and usually disappear with continued use or by reduction of the dose. Rare case of mild psychic disturbances was also reported which subsided after few days of treatment, Gastrointestinal reactions such as nausea, vomiting, diarrhoea, epigastric and abdominal pain are often due to large doses of the drug and disappear when the dose is reduced. Administration of the capsule immediately after meals with an antacid it necessary, minimize the frequency and the severity of these untoward effects.

Precaution

Indomethacin capsule should be used with caution with psychiatric problems, epilepsy or parkinsonism since the drug may aggravate these conditions. It is not recommended for pregnant women, because at the present time clinical studies are insufficient. Indomethacin is not given nomally in neonates except when used to assist closure of a patent ductus arteriosus.

Interaction

It may interact with anticoagulants, Lithium, diuretics, antihypertensive drugs, diflunisal and sulfonylureas.

Contraindication

Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and it should be used with caution in patients with a history of these disorders. In these cases, administration of Indomethacin suppositories should be preferred. It is also contraindicated in the previously hypersensitive patients.

Storage Condition

Store in a cool and dry place protected from light. Keep out of the reach of children.

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