Inecalcitol Uses, Dosage, Side Effects and more
| Trade Name | Inecalcitol |
| Generic | Inecalcitol |
| Inecalcitol Other Names | Inecalcitol |
| Type | |
| Formula | C26H40O3 |
| Weight | Average: 400.603 Monoisotopic: 400.297745148 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
How Inecalcitol works
Inecalcitol is an analogue of calcitriol, the naturally active metabolite of vitamin D. Calcitriol and their analogues activate the vitamin D receptor (VDR). Vitamin D has a major role in regulating calcium absorption from the gut, storage in mineral form in the bones, and excretion by the kidney and effectively prevents rickets in infants. Vitamin D and calcitriol can cause hypercalcemia at high or frequently repeated doses; in turn, hypercalcemia can cause kidney toxicity by accumulation of calcium-containing micro-crystals and heart and muscle dysfunction by impairing contractions. [Hybrigenics Website] The mechanism of action is currently unknown, but it is proposed that inecalcitol exerts its superagonistic action through enhancing coactivator binding by the VDR.
