Inecalcitol
Inecalcitol Uses, Dosage, Side Effects, Food Interaction and all others data.
| Trade Name | Inecalcitol |
| Generic | Inecalcitol |
| Inecalcitol Other Names | Inecalcitol |
| Type | |
| Formula | C26H40O3 |
| Weight | Average: 400.603 Monoisotopic: 400.297745148 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
How Inecalcitol works
Inecalcitol is an analogue of calcitriol, the naturally active metabolite of vitamin D. Calcitriol and their analogues activate the vitamin D receptor (VDR). Vitamin D has a major role in regulating calcium absorption from the gut, storage in mineral form in the bones, and excretion by the kidney and effectively prevents rickets in infants. Vitamin D and calcitriol can cause hypercalcemia at high or frequently repeated doses; in turn, hypercalcemia can cause kidney toxicity by accumulation of calcium-containing micro-crystals and heart and muscle dysfunction by impairing contractions. [Hybrigenics Website] The mechanism of action is currently unknown, but it is proposed that inecalcitol exerts its superagonistic action through enhancing coactivator binding by the VDR.
Innovators Monograph
You find simplified version here Inecalcitol
