INOflo

INOflo Uses, Dosage, Side Effects, Food Interaction and all others data.

Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.

Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.

The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.

Trade Name INOflo
Generic Nitric Oxide
Nitric Oxide Other Names EDRF, endothelium-derived relaxing factor, Mononitrogen monoxide, Monóxido de nitrógeno, Monoxyde d'azote, Nitric Oxide, Nitrogen monooxide, Nitrogen monoxide, Nitrosyl, NO, óxido de nitrógeno(II), óxido nítrico, Oxyde azotique, Oxyde nitrique, Stickstoff(II)-oxid, Stickstoffmonoxid
Type
Formula NO
Weight Average: 30.0061
Monoisotopic: 29.997988627
Groups Approved
Therapeutic Class
Manufacturer
Available Country Japan
Last Updated: September 19, 2023 at 7:00 am
INOflo
INOflo

Uses

INOflo is a vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates.

For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure

INOflo is also used to associated treatment for these conditions: Hypoxic Respiratory Failure

How INOflo works

Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.

Food Interaction

No interactions found.

Elimination Route

Nitric oxide is absorbed systemically after inhalation.

Half Life

2–6 seconds

Elimination Route

Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.

Innovators Monograph

You find simplified version here INOflo

*** Taking medicines without doctor's advice can cause long-term problems.
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