INOflo
INOflo Uses, Dosage, Side Effects, Food Interaction and all others data.
Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.
Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant.
The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
| Trade Name | INOflo |
| Generic | Nitric Oxide |
| Nitric Oxide Other Names | EDRF, endothelium-derived relaxing factor, Mononitrogen monoxide, Monóxido de nitrógeno, Monoxyde d'azote, Nitric Oxide, Nitrogen monooxide, Nitrogen monoxide, Nitrosyl, NO, óxido de nitrógeno(II), óxido nítrico, Oxyde azotique, Oxyde nitrique, Stickstoff(II)-oxid, Stickstoffmonoxid |
| Type | |
| Formula | NO |
| Weight | Average: 30.0061 Monoisotopic: 29.997988627 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Japan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
INOflo is a vasodilating agent used in the treatment of hypoxic respiratory failure in premature neonates.
For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
INOflo is also used to associated treatment for these conditions: Hypoxic Respiratory Failure
How INOflo works
Nitric oxide is a compound produced by many cells of the body. It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation. When inhaled, nitric oxide produces pulmonary vasodilation.
Food Interaction
No interactions found.Elimination Route
Nitric oxide is absorbed systemically after inhalation.
Half Life
2–6 seconds
Elimination Route
Nitrate has been identified as the predominant nitric oxide metabolite excreted in the urine, accounting for >70% of the nitric oxide dose inhaled.
Innovators Monograph
You find simplified version here INOflo
