Inseal A
Inseal A Uses, Dosage, Side Effects, Food Interaction and all others data.
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring, which attaches a valeric acid substituent at one of its carbon atoms. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes.
Selenium is a trace metal in the human body particularly important as a component of glutathione peroxidase, an important enzyme in the prevention of cellular damage by free radicals and reactive oxygen species
Selenium is incorporated into many different selenoproteins which serve various functions throughout the body .
Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and with decreased symptom severity.
Although it has been nasally administered for treating the common cold, this route of administration has been associated with some cases of anosmia , , , .
Studies show that zinc may be better absorbed in humans in the gluconate form , , however, results from other studies may vary , [L27280].
| Trade Name | Inseal A |
| Generic | Biotin + D Chiro Inositol + Myo Inositol + N Acetylcysteine + Selenium + Zinc Gluconate |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | El V Life Sciences |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Biotin is a B-complex vitamin found in many multivitamin products.
For nutritional supplementation, also for treating dietary shortage or imbalance.
Selenium is an ingredient found in a variety of supplements and vitamins.
For the supplementation of total parenteral nutrition to prevent hyposelenemia .
Zinc gluconate is an ingredient found in a variety of supplements and vitamins.
Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea .
Inseal A is also used to associated treatment for these conditions: Vitamin Deficiency, Nutritional supplementationNutritional supplementationZinc Deficiency
How Inseal A works
Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
Selenium is first metabolized to selenophosphate and selenocysteine. Selenium incorporation is genetically encoded through the RNA sequence UGA . This sequence is recognized by RNA ste loop structures called selenocysteine inserting sequences (SECIS). These structures require the binding of SECIS binding proteins (SBP-2) to recognize selenocystiene. The specialized tRNA is first bound to a serine residue which is then enzymatically processed to a selylcysteyl-tRNA by selenocystiene sythase using selenophosphate as a selenium donor. Other unidentified proteins are required as part of the binding of this tRNA to the ribosome. Selenoproteins appear to be necessary for life as mice with the specialized tRNA gene knocked out exhibited early embryonic lethality .
The most important selenoproteins seem to be the glutathione peroxidases and thioredoxin reductases which are part of the body's defenses againts reactive oxygen species (ROS) . The importance of selenium in these anti-oxidant proteins has been implicated in the reduction of atherosclerosis by preventing the oxidation of low density lipoprotein . Selenium supplementation is also being investigated in the prevention of cancer and has been suggested to be beneficial to immune function .
Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV) .
Toxicity
Prolonged skin contact may cause irritation.
Oral LD50 of 6700mg/kg in rats . Selenium exposure is teratogenic and can result in fetal death as tested in mice. Chronic toxicity is characterized by hair loss, white horizontal streaking on fingernails, paronchyia, fatigue, irritability, hyperreflexia, nausea, vomiting, garlic odor on breath, and metallic taste . Serum selenium correlates weakly with symtoms. Blood chemistry as well as liver and kidney function are normally unnaffected. Acute toxicity presents as stupor, respiratory depression, and hypotension. ST elevations and t-wave changes characteristic of myocardial infarction may be observed.
Nausea, vomiting, diarrhea, and mouth irritation have been reported in patients ingesting zinc gluconate tablets that were dissolved in the mouth for management the common cold .
Zinc crosses the placenta and is found the cord blood and placenta. Fetal concentrations are regulated by the placenta .
For more information, refer to Please refer to DrugBank entry Zinc.
Acute: 1290 mg/kg in mouse
Volume of Distribution
Stored primarily in skeletal muscle and bone .
Elimination Route
Systemic - approximately 50%
Oral bioavailability of 90% when given as L-selenomethionine . Tmax of 9.17h.
Please refer to DrugBank entry Zinc
Half Life
Half life was observed to increase with chronic dosing time . For day 1-2 half life was 1.7 days. For day 2-3 half life was 3 days. For day 3-14 half life was 11.1 days.
280 days
Clearance
Please refer to DrugBank entry Zinc
Elimination Route
Mainly excreted in urine as 1beta-methylseleno-N-acetyl-d-galactosamine and trimethylselenonium . The amount excreted as 1beta-methylseleno-N-acetyl-d-galactosamine plateaus at doses around 2microg after which the amount excreted as trimethylselenonium increases. Some selenium is also excreted in feces when given orally .
Feces and urine
Innovators Monograph
You find simplified version here Inseal A
