Interferon Alpha-n1 (INS)

Interferon Alpha-n1 (INS) Uses, Dosage, Side Effects, Food Interaction and all others data.

Interferon Alpha-n1 (INS) consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes.

Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.

Interferon Alpha-n1 (INS)
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Interferon Alpha-n1 (INS)
Generic	Interferon alfa-n1
Interferon alfa-n1 Other Names	Interferon alfa-n1, Interferon alpha-n1 (INS)
Type
Formula	C₈₆₀H₁₃₅₃N₂₂₇O₂₅₅S₉
Weight	19241.1 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Interferon Alpha-n1 (INS) is a purified form of human interferon used to stimulate the innate antiviral response in the treatment of genital warts due to human papilloma virus.

For the treatment of venereal or genital warts caused by the Human Papiloma Virus.

How Interferon Alpha-n1 (INS) works

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.