Ipride Sr

Ipride Sr Uses, Dosage, Side Effects, Food Interaction and all others data.

Ipride Sr is a dopamine D2 antagonist with acetylcholinesterase inhibitory actions.

Trade Name Ipride Sr
Generic Itopride
Itopride Other Names Itopride
Weight 150mg
Type Capsule
Formula C20H26N2O4
Weight Average: 358.4314
Monoisotopic: 358.18925733
Groups Investigational
Therapeutic Class
Manufacturer Wilshire Laboratories (pvt) Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Ipride Sr
Ipride Sr

Uses

Ipride Sr is an acetylcholine esterase inhibitor and dopamine D2 receptor antagonist used to treat symptoms of functional dyspepsia such as nausea and vomiting.

Investigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous).

Ipride Sr is also used to associated treatment for these conditions: Abdominal Pain, Dyspepsia, Functional Dyspepsia, Gastroenteritis, Loss of Appetite, Nausea, Nausea and vomiting, Vomiting, Abdominal bloating, Pyrosis, Stomach discomfort

How Ipride Sr works

Ipride Sr has anticholinesterase (AchE) activity as well as dopamine D2 receptor antagonistic activity. It is well established that M3 receptors exist on the smooth muscle layer throughout the gut and acetylcholine (ACh) released from enteric nerve endings stimulates the contraction of smooth muscle through M3 receptors. The enzyme AChE hydrolyses the released ACh, inactivates it and thus inhibits the gastric motility leading to various digestive disorders. Besides ACh, dopamine is present in significant amounts in the gastrointestinal tract and has several inhibitory effects on gastrointestinal motility, including reduction of lower esophageal sphincter and intragastric pressure. These effects appear to result from suppression of ACh release from the myenteric motor neurons and are mediated by the D2 subtype of dopamine receptors. Ipride Sr, by virtue of its dopamine D2 receptor antagonism, removes the inhibitory effects on Ach release. It also inhibits the enzyme AchE which prevents the degradation of ACh. The net effect is an increase in ACh concentration, which in turn, promotes gastric motility, increases the lower esophageal sphincter pressure, accelerates gastric emptying and improves gastro-duodenal coordination. This dual mode of action of Ipride Sr is unique and different from the actions of other prokinetic agents available in the market.

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*** Taking medicines without doctor's advice can cause long-term problems.
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