Iron(III) Pyrophosphate
Iron(III) Pyrophosphate Uses, Dosage, Side Effects, Food Interaction and all others data.
Iron(III) Pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate. It presents an increasing interest as this insoluble form can be milder in the gastrointestinal tract and present higher bioavailability.
Iron supplementation typically results in increases in serum iron, transferrin-bound iron, and iron-stored in the form of ferritin in hepatocytes and macrophages. The available iron is usually used in bone marrow for the synthesis of hemoglobin.
| Trade Name | Iron(III) Pyrophosphate |
| Generic | Ferric pyrophosphate |
| Ferric pyrophosphate Other Names | Iron pyrophosphate, Iron(III) pyrophosphate |
| Type | |
| Formula | Fe4O21P6 |
| Weight | Average: 745.21 Monoisotopic: 745.475544666 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Iron(III) Pyrophosphate is intended to be indicated for the treatment of iron loss or iron deficiency as a formulation with a milder gastrointestinal effect.
Iron deficiency appears when the dietary intake does not meet the body's requirement or when there is chronic external blood loss. During acute blood loss, body iron stores are sufficient for accelerated erythropoiesis and restoration of iron homeostasis. But when the altered homeostasis remains for weeks to months then some supplement is needed. Some causes of iron deficiency include ectoparasitism, endoparasitism, hematuria, epistaxis, hemorrhagic skin, coagulopathy, thrombocytopenia, thrombocytopathia and gastrointestinal hemorrhage.
Iron(III) Pyrophosphate is also used to associated treatment for these conditions: Hemodialysis-dependent chronic kidney disease (HDD-CKD), Iron replacement therapy
How Iron(III) Pyrophosphate works
The usage of ferric pyrophosphate is based on the strong complex formation between these two species. Besides, the capacity of pyrophosphate to trigger iron removal from transferrin, enhance iron transfer from transferrin to ferritin and promote iron exchange between transferrin molecules. These properties make it a very suitable compound for parenteral administration, iron delivery into circulation and incorporation into hemoglobin.
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