Isoamyl P-methoxycinnamate
Isoamyl P-methoxycinnamate Uses, Dosage, Side Effects, Food Interaction and all others data.
Isoamyl P-methoxycinnamate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m . It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Isoamyl P-methoxycinnamate is a cinnamic acid derivative with an anti-inflammatory activity .
In a mouse study, amiloxate exerted a dose-dependent anti-inflammatory action and inhibited edema by about 70% even at a low dose . Due to structural similarities, amiloxate may also display antioxidant and antimicrobial properties of cinnamic acid .
| Trade Name | Isoamyl P-methoxycinnamate |
| Generic | Amiloxate |
| Amiloxate Other Names | Amiloxate, Isoamyl p-methoxycinnamate |
| Type | |
| Formula | C15H20O3 |
| Weight | Average: 248.322 Monoisotopic: 248.141244504 |
| Protein binding | No pharmacokinetic data available. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Indicated as an active sunscreen agent.
Isoamyl P-methoxycinnamate is also used to associated treatment for these conditions: Sunburn
How Isoamyl P-methoxycinnamate works
Isoamyl P-methoxycinnamate is a UV-B filter that selectively absorbs UV-B rays . It is proposed that amiloxate mediates an antioxidant action by acting as a free radical scavenger .
Toxicity
Oral LD50 in rat is 9600 mg/kg .
Food Interaction
No interactions found.Volume of Distribution
No pharmacokinetic data available.
Elimination Route
According to in vitro studies of amiloxate-containing tape strips on porcine ear, there was no detection of amiloxate undergoing skin penetration .
Half Life
No pharmacokinetic data available.
Clearance
No pharmacokinetic data available.
Elimination Route
No pharmacokinetic data available.
Innovators Monograph
You find simplified version here Isoamyl P-methoxycinnamate
