Jaizzy
Jaizzy Uses, Dosage, Side Effects, Food Interaction and all others data.
Jaizzy is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Jaizzy is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Jaizzy |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Type | Capsule |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | Aamorb Pharmaceuticals Pvt Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Jaizzy is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Jaizzy is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Jaizzy works
Jaizzy's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Jaizzy
FAQ
What is Jaizzy used for?
Jaizzy is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Jaizzy?
Jaizzy is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Jaizzy has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Jaizzy as a first-line pharmacological background treatment of osteoarthritis.
How does Jaizzy work?
Jaizzy works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Jaizzy?
Common side effects of Jaizzy are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Jaizzy safe during pregnancy?
Jaizzy should not be administered during pregnancy.
Is Jaizzy safe during breastfeeding?
Jaizzy should not be administered during lactation.
Can I drink alcohol with Jaizzy?
Patients should be advised to limit their alcohol intake while on treatment with Jaizzy.
Can I drive after taking Jaizzy?
Jaizzy may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Jaizzy?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Jaizzy on an empty stomach?
The Jaizzy should be taken with food, one with breakfast and the other with evening meal.
How often can I take Jaizzy?
The recommended dose is 50 mg to be taken twice daily.
How long does Jaizzy take to work ?
Jaizzy starts showing its action in 2-3 hours. The duration of action of Jaizzy is 27 hours
How long can Jaizzy be taken?
The duration of action of Jaizzy is 27 hours.
Who should not take Jaizzy?
Jaizzy should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Jaizzy an antibiotic?
Jaizzy is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Jaizzy?
If you forget to take a dose of Jaizzy, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Jaizzy?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Jaizzy.
Can Jaizzy causes diarrhoea?
Jaizzy may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Jaizzy?
Avoid taking Jaizzy if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Jaizzy is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Jaizzy affects my heart ?
Jaizzy Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Jaizzy cause kidney damage?
Jaizzy has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Jaizzy affects my liver?
Around 0.5% of patients on Jaizzy had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
