Jetepar
Jetepar Uses, Dosage, Side Effects, Food Interaction and all others data.
Ethanolamine oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
When injected intravenously, ethanolamine oleate acts primarily by irritation of the intimal endothelium of the vein and produces a sterile dose-related inflammatory response. This results in fibrosis and possible occlusion of the vein. Ethanolamine oleate also rapidly diffuses through the venous wall and produces a dose-related extravascular inflammatory reaction.
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
| Trade Name | Jetepar |
| Generic | Betaine Glucuronate + Nicotinamide + Ethanolamine Oleate |
| Weight | 150mg, 8.2mg, 75mg/ml, 20mg/ml, 4.1mg/ml, 200mg/5ml, 10mg/5ml |
| Type | Capsule, Injection, Syrup |
| Therapeutic Class | |
| Manufacturer | Popular Chemical Works (pvt) Ltd, |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ethanolamine oleate is a mild sclerosing agent used in the treatment of esophageal varices with recent bleeding episodes.
For the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding.
Nicotinamide is an ingredient found in a variety of cosmetic products.
Jetepar is also used to associated treatment for these conditions: Varices, EsophagealGastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation, Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation
How Jetepar works
The oleic acid component of ethanolamine oleate is responsible for the inflammatory response, and may also activate coagulation in vivo by release of tissue factor and activation of Hageman factor. The ethanolamine component, however, may inhibit fibrin clot formation by chelating calcium, so that a procoagulant action of ethanolamine oleate has not been demonstrated.
Toxicity
The minimum lethal dose administered intravenously to rabbits is 130 mg/kg. Overdosage can result in severe intramural necrosis of the esophagus. Complications resulting from such overdosage have resulted in death. LD50 (intravenous) in rats is 156 mg/kg. LD50 (intravenous) in dogs is 175 mg/kg.
Elimination Route
After injection into an esophageal varix, ethanolamine oleate is cleared from the injection site within five minutes via the portal vein. Some of the medication also flows into the azygos vein through the periesophageal vein if more than 20 mL is injected.
Innovators Monograph
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